Surgery for urinary incontinence in women: Report from the 6th international consultation on incontinence
Corresponding Author
Alex Gomelsky
Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
Correspondence
Alex Gomelsky, MD, LSU Health − Shreveport, Department of Urology, 1501 Kings Highway, Shreveport, LA 71130.
Email: [email protected]
Search for more papers by this authorStavros Athanasiou
1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Alexandra” Hospital, Athens, Greece
Search for more papers by this authorMyung-Soo Choo
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorRoger R. Dmochowski
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
Search for more papers by this authorCristiano M. Gomes
Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Search for more papers by this authorCharles W. Nager
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, California
Search for more papers by this authorRoy Ng
Division of Urogynaecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynaecology, National University Hospital, Singapore
Search for more papers by this authorEric S. Rovner
Department of Urology, Medical University of South Carolina, Charleston, South Carolina
Search for more papers by this authorPeter Sand
Division of Urogynecology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Skokie, Illinois
Search for more papers by this authorHikaru Tomoe
Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Alex Gomelsky
Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
Correspondence
Alex Gomelsky, MD, LSU Health − Shreveport, Department of Urology, 1501 Kings Highway, Shreveport, LA 71130.
Email: [email protected]
Search for more papers by this authorStavros Athanasiou
1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Alexandra” Hospital, Athens, Greece
Search for more papers by this authorMyung-Soo Choo
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorRoger R. Dmochowski
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
Search for more papers by this authorCristiano M. Gomes
Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Search for more papers by this authorCharles W. Nager
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, California
Search for more papers by this authorRoy Ng
Division of Urogynaecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynaecology, National University Hospital, Singapore
Search for more papers by this authorEric S. Rovner
Department of Urology, Medical University of South Carolina, Charleston, South Carolina
Search for more papers by this authorPeter Sand
Division of Urogynecology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Skokie, Illinois
Search for more papers by this authorHikaru Tomoe
Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan
Search for more papers by this authorAbstract
Urinary incontinence is a prevalent condition worldwide and causes a tremendous impact on a woman's quality of life. While conservative and non-surgical therapies are options for treatment, surgery for stress urinary incontinence (SUI) is common. Options include colposuspension, slings (pubovaginal and midurethral), and periurethral bulking. While evidence supports each of these options in the treatment of SUI, each is associated with various rates of success and unique adverse event profiles. Urgency urinary incontinence (UUI) is initially treated with behavioral modification and pharmacologic means, with surgery reserved for those with refractory symptoms or significant complications from medication use. At present, intravesical onabotulinumtoxinA injections, percutaneous tibial nerve stimulation, and sacral neurostimulation are all viable options for refractory UUI/overactive bladder. As with surgical interventions for SUI, each of these is, likewise, associated with unique outcomes and adverse event profiles. Herein, we summarize the findings and conclusions from the 6th International Consultation on Incontinence (ICI) regarding surgical treatment of urinary incontinence in women.
REFERENCES
- 1 Dmochowski R, Athanasiou S, Reid F, et al. Committee 14: surgery for urinary incontinence in women. In: P Abrams, L Cardozo, S Khoury, A Wein, editors. 5th International Consultation on Incontinence ( 5th ed.). ICUD-EAU 2012; 2013. pp. 1307–1375.
- 2 Giordano VD. Twentieth IEME congress. Franco de Chirug. 1907; 506.
- 3 Rehman H, Bezerra CC, Bruschini H, Cody JD. Traditional suburethral sling operations for urinary incontinence in women. Cochrane Database Syst Rev. 2011; 1: CD001754.
- 4 Rehman H, Bezerra CA, Bruschini H, Cody JD, Aluko P. Traditional suburethral sling operations for urinary incontinence in women. Cochrane Database Syst Rev. 2017; 7: CD001754.
- 5 Leone Roberti Maggiore U, Bogani G, Meschia M, et al. Urethral bulking agents versus other surgical procedures for the treatment of female stress urinary incontinence: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2015; 189: 48–54.
- 6 Lapitan MC, Cody JD. Open retropubic colposuspension for urinary incontinence in women. Cochrane Database Syst Rev. 2016; 2: CD002912.
- 7 Lapitan MCM, Cody JD, Mashayekhi A. Open retropubic colposuspension for urinary incontinence in women. Cochrane Database Syst Rev. 2017; 7: CD002912.
- 8 Ulmsten U, Henriksson L, Johnson P, Varhos G. An ambulatory surgical procedure under local anesthesia for treatment of female urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 1996; 7: 81–85.
- 9 Ford AA, Rogerson L, Cody JD, Ogah J. Midurethral sling operations for stress urinary incontinence in women. Cochrane Database Syst Rev. 2015; 7: CD006375.
- 10 Labrie J, Berghmans BL, Fischer K, et al. Surgery versus physiotherapy for stress urinary incontinence. N Engl J Med. 2013; 369: 1124–1133.
- 11 Costantini E, Kocjancic E, Lazzeri M, et al. Long-term efficacy of the trans-obturator and retropubic mid-urethral slings for stress urinary incontinence: update from a randomized clinical trial. World J Urol. 2016; 34: 585–593.
- 12 Brennand EA, Tang S, Williamson T, et al. Twelve-month outcomes following midurethral sling procedures for stress incontinence: impact of obesity. BJOG. 2015; 122: 1705–1712.
- 13 Kenton K, Stoddard AM, Zyczynski H, et al. 5-year longitudinal followup after retropubic and transobturator mid urethral slings. J Urol. 2015; 193: 203–210.
- 14 Cavkaytar S, Kokanali MK, Guzel AI, Ozer I, Aksakal OS, Doganay M. Comparison of TVT and TOT on urethral mobility and surgical outcomes in stress urinary incontinence with hypermobile urethra. Eur J Obstet Gynecol Reprod Biol. 2015; 190: 36–40.
- 15 Bohlin KS, Ankardal M, Pedroletti C, Lindkvist H, Milsom I. The influence of the modifiable lifestyle factors body mass index and smoking on the outcome of mid-urethral sling procedures for female urinary incontinence. Int Urogynecol J. 2015; 26: 343–351.
- 16 Jeong SJ, Lee HS, Lee JK, et al. The long-term influence of body mass index on the success rate of mid-urethral sling surgery among women with stress urinary incontinence or stress-predominant mixed incontinence: comparisons between retropubic and transobturator approaches. PLoS ONE. 2014; 9: e113517.
- 17 Laurikainen E, Valpas A, Aukee P, et al. Five-year results of a randomized trial comparing retropubic and transobturator midurethral slings for stress incontinence. Eur Urol. 2014; 65: 1109–1114.
- 18 Zyczkowski M, Nowakowski K, Kuczmik W, et al. Tension-free vaginal tape, transobturator tape, and own modification of transobturator tape in the treatment of female stress urinary incontinence: comparative analysis. Biomed Res Int. 2014; 2014: 347856.
- 19 Albo ME, Litman HJ, Richter HE, et al. Treatment success of retropubic and transobturator mid urethral slings at 24 months. J Urol. 2012; 188: 2281–2287.
- 20 Ballester M, Bui C, Frobert JL, et al. Four-year functional results of the suburethral sling procedure for stress urinary incontinence: a French prospective randomized multicentre study comparing the retropubic and transobturator routes. World J Urol. 2012; 30: 117–122.
- 21 Darai E, Frobert JL, Grisard-Anaf M, et al. Functional results after the suburethral sling procedure for urinary stress incontinence: a prospective randomized multicentre study comparing the retropubic and transobturator routes. Eur Urol. 2007; 51: 795–801.
- 22 Laurikainen E, Valpas A, Kivelä A, et al. Retropubic compared with transobturator tape placement in treatment of urinary incontinence: a randomized controlled trial. Obstet Gynecol. 2007; 109: 4–11.
- 23 Porena M, Costantini E, Frea B, et al. Tension-free vaginal tape versus Transobturator tape as surgery for stress urinary incontinence: results of a multicentre randomised trial. Eur Urol. 2007; 52: 1481–1491.
- 24 Palva K, Rinne K, Aukee P, et al. A randomized trial comparing tension-free vaginal tape with tension-free vaginal tape-obturator: 36-month results. Int Urogynecol J. 2010; 21: 1049–1055.
- 25 Richter HE, Albo ME, Zyczynski HM, et al. Urinary Incontinence Treatment Network. Retropubic versus transobturator midurethral slings for stress incontinence. N Engl J Med. 2010; 362: 2066–2076.
- 26 Costantini E, Lazzeri M, Zucchi A, Di Biase M, Porena M. Long-term efficacy of the transobturator and retropubic mid-urethral slings for stress urinary incontinence: single-center update from a randomized controlled trial. Eur Urol. 2014; 66: 599–601.
- 27 Nambiar A, Cody JD, Jeffery ST. Single-incision sling operations for urinary incontinence in women. Cochrane Database Syst Rev. 2014; 6: CD008709.
- 28 Nambiar A, Cody JD, Jeffery ST, Aluko P. Single-incision sling operations for urinary incontinence in women. Cochrane Database Syst Rev. 2017; 7: CD008709.
- 29
Abdelwahab O,
Shedid I,
Al-Adl AM. Tension-free vaginal tape versus secure tension-free vaginal tape in treatment of female stress urinary incontinence.
Curr Urol.
2010; 4: 93–98.
10.1159/000253420 Google Scholar
- 30 Wang YJ, Li FP, Wang Q, Yang S, Cai XG, Chen YH. Comparison of three mid-urethral tension-free tapes (TVT, TVT-O, and TVT-Secur) in the treatment of female stress urinary incontinence: 1-year follow up. Int Urogynecol J. 2011; 22: 1369–1374.
- 31 Barber MD, Weidner AC, Sokol AI, et al. Single-incision mini-sling compared with tension-free vaginal tape for the treatment of stress urinary incontinence: a randomized controlled trial. Obstet Gynecol. 2012; 119: 328–337.
- 32 Andrada Hamer M, Larsson PG, Teleman P, Bergqvist CE, Persson J. One-year results of a prospective randomized, evaluator-blinded, multicenter study comparing TVT and TVT Secur. Int Urogynecol J. 2013; 24: 223–229.
- 33 Basu M, Duckett J. Three-year results from a randomised trial of a retropubic mid-urethral sling versus the Miniarc single incision sling for stress urinary incontinence. Int Urogynecol J. 2013; 24: 2059–2064.
- 34 Ross S, Tang S, Schulz J, et al. Single incision device (TVT Secur) versus retropubic tension-free vaginal tape device (TVT) for the management of stress urinary incontinence in women: a randomized clinical trial. BMC Res Notes. 2014; 7: 941.
- 35 Delorme E. Transobturator urethral suspension: mini-invasive procedure in the treatment of stress urinary incontinence in women. Prog Urol. 2001; 11: 1306–1313.
- 36 de Leval J. Novel surgical technique for the treatment of female stress urinary incontinence: transobturator vaginal tape inside-out. Eur Urol. 2003; 44: 724–730.
- 37 Madhuvrata P, Riad M, Ammembal MK, Agur W, Abdel-Fattah M. Systematic review and meta-analysis of “inside-out” versus ”outside-in” transobturator tapes in management of stress urinary incontinence in women. Eur J Obstet Gynecol Reprod Biol. 2012; 162: 1–10.
- 38 Mostafa A, Lim CP, Hopper L, Madhuvrata P, Abdel-Fattah M. Single-incision mini-slings versus standard midurethral slings in surgical management of female stress urinary incontinence: an updated systematic review and meta-analysis of effectiveness and complications. Eur Urol. 2014; 65: 402–427.
- 39 Moalli P, Brown B, Reitman MT, Nager CW. Polypropylene mesh: evidence for lack of carcinogenicity. Int Urogynecol J. 2014; 25: 573–576.
- 40 Chughtai B, Sedrakyan A, Mao J, et al. Challenging the myth: transvaginal mesh is not associated with carcinogenesis. J Urol. 2017; 198: 884–889.
- 41 Chughtai B, Sedrakyan A, Mao J, et al. No increased risk of carcinogenesis with mesh-based hernia repairs. Am J Surg. 2018; 216: 481–486.
- 42 Dissaranan C, Cruz MA, Couri BM, Goldman HB, Damaser MS. Stem cell therapy for incontinence: where are we now? What is the realistic potential? Curr Urol Rep. 2011; 12: 336–344.
- 43 Lee C, Chermansky CJ, Damaser MS. Translational approaches to the treatment of benign urologic conditions in elderly women. Curr Opin Urol. 2016; 26: 184–192.
- 44 Tran C, Damaser MS. The potential role of stem cells in the treatment of urinary incontinence. Ther Adv Urol. 2015; 7: 22–40.
- 45 Vaegler M, Lenis AT, Daum L, et al. Stem cell therapy for voiding and erectile dysfunction. Nat Rev Urol. 2012; 9: 435–447.
- 46 Yu A, Campeau L. Bone marrow mesenchymal stem cell therapy for voiding dysfunction. Curr Urol Rep. 2015; 16: 49.
- 47 Chung E. Stem-cell-based therapy in the field of urology: a review of stem cell basic science, clinical applications and future directions in the treatment of various sexual and urinary conditions. Expert Opin Biol Ther. 2015; 15: 1623–1632.
- 48 Zhou S, Zhang K, Atala A, et al. Stem cell therapy for treatment of stress urinary incontinence: the current status and challenges. Stem Cells Int. 2016; 2016: 7060975.
- 49 Wang Z, Wen Y, Li YH, et al. Smooth muscle precursor cells derived from human pluripotent stem cells for treatment of stress urinary incontinence. Stem Cells Dev. 2016; 25: 453–461.
- 50 Kuismanen K, Sartoneva R, Haimi S, et al. Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study. Stem Cells Translat Med. 2014; 3: 936–941.
- 51 Gras S, Klarskov N, Lose G. Intraurethral injection of autologous minced skeletal muscle: a simple surgical treatment for stress urinary incontinence. J Urol. 2014; 192: 850–855.
- 52 Carr LK, Robert M, Kultgen PL, et al. Autologous muscle derived cell therapy for stress urinary incontinence: a prospective, dose ranging study. J Urol. 2013; 189: 595–601.
- 53 Peters KM, Dmochowski RR, Carr LK, et al. Autologous muscle derived cells for treatment of stress urinary incontinence in women. J Urol. 2014; 192: 469–476.
- 54 Stangel-Wojcikiewicz K, Jarocha D, Piwowar M, et al. Autologous muscle-derived cells for the treatment of female stress urinary incontinence: a 2-year follow-up of a Polish investigation. Neurourol Urodyn. 2014; 33: 324–330.
- 55 Blaganje M, Lukanovic A. Intrasphincteric autologous myoblast injections with electrical stimulation for stress urinary incontinence. Int J Gynaecol Obstet. 2012; 117: 164–167.
- 56 Pokrywczynska M, Adamowicz J, Czapiewska M, et al. Targeted therapy for stress urinary incontinence: a systematic review based on clinical trials. Expert Opin Biol Ther. 2016; 16: 233–242.
- 57 Kang D, Han J, Neuberger MM, et al. Transurethral radiofrequency collagen denaturation for the treatment of women with urinary incontinence. Cochrane Database Syst Rev. 2015; 3: CD010217.
- 58 Appell RA, Juma S, Wells WG, et al. Transurethral radiofrequency energy collagen micro-remodeling for the treatment of female stress urinary incontinence. Neurourol Urodyn. 2006; 25: 331–336.
- 59 Herbison GP, Arnold EP. Sacral neuromodulation with implanted devices for urinary storage and voiding dysfunction in adults. Cochrane Database Syst Rev. 2009; 2: CD004202.
- 60 Siegel S, Noblett K, Mangel J, et al. Results of a prospective, randomized, multicenter study evaluating sacral neuromodulation with InterStim therapy compared to standard medical therapy at 6-months in subjects with mild symptoms of overactive bladder. Neurourol Urodyn. 2015; 34: 224–230.
- 61 Noblett K, Siegel S, Mangel J, et al. Results of a prospective, multicenter study evaluating quality of life, safety, and efficacy of sacral neuromodulation at twelve months in subjects with symptoms of overactive bladder. Neurourol Urodyn. 2016; 35: 246–251.
- 62 Siegel S, Noblett K, Mangel J, et al. Three-year follow-up results of a prospective, multicenter study in overactive bladder subjects treated with sacral neuromodulation. Urology. 2016; 94: 57–63.
- 63 Amundsen CL, Richter HE, Menefee S, et al. Sacral neuromodulation versus onabotulinumtoxin A for refractory overactive bladder. JAMA. 2016; 316: 1366–1374.
- 64Full Prescribing Information for BOTOX (onabotulinumtoxinA) https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103000s5302lbl.pdf (accessed October 1, 2018).
- 65 Gormley EA, Lightner DJ, Faraday M, Vasavada SP. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment. J Urol. 2015; 193: 1572–1580.
- 66 Peters KM, Carrico DJ, Perez-Marrero RA, et al. Randomized trial of percutaneous tibial nerve stimulation versus Sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT trial. J Urol. 2010; 183: 1438–1443.
- 67 Finazzi-Agro E, Petta F, Sciobica F, Pasqualetti P, Musco S, Bove P. Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial. J Urol. 2010; 184: 2001–2006.
- 68 Peters KM, MacDiarmid SA, Wooldridge LS, et al. Randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the overactive bladder innovative therapy trial. J Urol. 2009; 182: 1055–1061.
- 69 MacDiarmid SA, Peters KM, Shobeiri SA, et al. Long-term durability of percutaneous tibial nerve stimulation for the treatment of overactive bladder. J Urol. 2010; 183: 234–240.
- 70 Preyer O, Umek W, Laml T, et al. Percutaneous tibial nerve stimulation versus tolterodine for overactive bladder in women: a randomised controlled trial. Eur J Obstet Gynecol Reprod Biol. 2015; 191: 51–56.
- 71 Vecchioli-Scaldazza C, Morosetti C, Berouz A, Giannubilo W, Ferrara V. Solifenacin succinate versus percutaneous tibial nerve stimulation in women with overactive bladder syndrome: results of a randomized controlled crossover study. Gynecol Obstet Invest. 2013; 75: 230–234.
- 72 Gaziev G, Topazio L, Iacovelli V, et al. Percutaneous Tibial Nerve Stimulation (PTNS) efficacy in the treatment of lower urinary tract dysfunctions: a systematic review. BMC Urol. 2013; 13: 61.
- 73 Moossdorff-Steinhauser HF, Berghmans B. Effects of percutaneous tibial nerve stimulation on adult patients with overactive bladder syndrome: a systematic review. Neurourol Urodyn. 2013; 32: 206–214.
- 74 Biemans JM, van Balken MR. Efficacy and effectiveness of percutaneous tibial nerve stimulation in the treatment of pelvic organ disorders: a systematic review. Neuromodulation. 2013; 16: 25–33.
- 75 Levin PJ, Wu JM, Kawasaki A, Weidner AC, Amundsen CL. The efficacy of posterior tibial nerve stimulation for the treatment of overactive bladder in women: a systematic review. Int Urogynecol J. 2012; 23: 1591–1597.
- 76 Burton C, Sajja A, Latthe PM. Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis. Neurourol Urodyn. 2012; 31: 1206–1216.
- 77 Wibisono E, Rahardjo HE. Effectiveness of short term percutaneous tibial nerve stimulation for non-neurogenic overactive bladder syndrome in adults: a meta-analysis. Acta Med Indonesiana. 2015; 47: 188–200.
- 78 Peters KM, Carrico DJ, Wooldridge LS, Miller CJ, MacDiarmid SA. Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder: 3-year results of the STEP study. J Urol. 2013; 189: 2194–2201.
- 79 Yoong W, Shah P, Dadswell R, Green L. Sustained effectiveness of percutaneous tibial nerve stimulation for overactive bladder syndrome: 2-year follow-up of positive responders. Int Urogynecol J. 2013; 24: 795–799.
- 80 Franzen K, Andersson G, Odeberg J, et al. Surgery for urinary incontinence in women 65 years and older: a systematic review. Int Urogynecol J. 2015; 26: 1095–1102.
- 81 Weltz V, Guldberg R, Lose G. Efficacy and perioperative safety of synthetic mid-urethral slings in obese women with stress urinary incontinence. Int Urogynecol J. 2015; 26: 641–648.
- 82 Agur W, Riad M, Secco S, et al. Surgical treatment of recurrent stress urinary incontinence in women: a systematic review and meta-analysis of randomised controlled trials. Eur Urol. 2013; 64: 323–336.
- 83 Nikolopoulos KI, Betschart C, Doumouchtsis SK. The surgical management of recurrent stress urinary incontinence: a systematic review. Acta Obstet Gynecol Scand. 2015; 94: 568–576.
- 84 Chai TC, Albo ME, Richter HE, et al. Complications in women undergoing Burch colposuspension versus autologous rectus fascial sling for stress urinary incontinence. J Urol. 2009; 181: 2192–2197.
- 85 Zyczynski HM, Albo ME, Goldman HB, et al. Change in overactive bladder symptoms after surgery for stress urinary incontinence in women. Obstet Gynecol. 2015; 126: 423–430.