Body composition and body mass index in Duchenne muscular dystrophy: Role of dietary intake
Mariela Bernabe-García MSc, PhD
Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc No. 330, Col. Doctores, Delegación Cuauhtémoc, 06725, Ciudad de México, México
Search for more papers by this authorCorresponding Author
Maricela Rodríguez-Cruz MSc, PhD
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Correspondence to: M. Rodríguez-Cruz; e-mail: [email protected]Search for more papers by this authorSalvador Atilano MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorOriana del Rocío Cruz-Guzmán MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorTomás Almeida-Becerril MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorPhilip C. Calder PhD
Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK
Search for more papers by this authorJulia González LDN
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorMariela Bernabe-García MSc, PhD
Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc No. 330, Col. Doctores, Delegación Cuauhtémoc, 06725, Ciudad de México, México
Search for more papers by this authorCorresponding Author
Maricela Rodríguez-Cruz MSc, PhD
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Correspondence to: M. Rodríguez-Cruz; e-mail: [email protected]Search for more papers by this authorSalvador Atilano MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorOriana del Rocío Cruz-Guzmán MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorTomás Almeida-Becerril MSc
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorPhilip C. Calder PhD
Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK
Search for more papers by this authorJulia González LDN
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México
Search for more papers by this authorFunding: Consejo Nacional de Ciencia y Tecnología (CONACyT), México (SALUD-2012-01-180058); Coordinación de Investigación en Salud, IMSS, México (FIS/IMSS/PROT/076); and Francaise Contre les Myopathies, France (FIS/IMSS/PROT/916).
Conflicts of Interest: None of the authors have any conflict of interest to disclose.
ABSTRACT
Introduction: In Duchenne muscular dystrophy (DMD) muscle is replaced by adipose tissue. The role of dietary intake (DI) in DMD has not been evaluated. In this study we examined body composition, body mass index (BMI), and adequacy of DI in patients with DMD and evaluated the influence of DI on body composition. Methods: Patients (n = 101; age 3–18 years; BMI 11.8–29.5 kg/m2) completed a dietary recall to determine DI and then underwent dual-energy X-ray absorptiometry to determine body composition. Results: Preschool-age and school-age boys with DMD had high total energy intake. Protein intake per kilogram exceeded recommendations. As age increased, the percentage of boys with abnormal BMI and fat mass increased, while lean mass decreased. Dietary intake did not predict body fat or lean mass. Discussion: Age-dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease-related mobility impairments. Muscle Nerve 59:295–302, 2019
Abstract
Supporting Information
| Filename | Description |
|---|---|
| mus26340-sup-0001-TableS1.docxWord 2007 document , 17 KB | Supplementary Table 1. Multivariate regression model to evaluate predictors of body fat mass (%) in boys with Duchenne muscular dystrophy. |
| mus26340-sup-0002-TableS2.docxWord 2007 document , 16.9 KB | Supplementary Table 2. Multivariate regression model to evaluate predictors of body lean mass (%) in boys with Duchenne muscular dystrophy. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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