Physical exercise during muscle regeneration improves recovery of the slow/oxidative phenotype
Nathalie Koulmann MD, PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Ecole du Val-de-Grâce, Paris, France
Search for more papers by this authorHélène Richard-Bulteau PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorBrigitte Crassous PharmD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorBernard Serrurier PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorMarielle Pasdeloup MSc
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorXavier Bigard MD, PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Ecole du Val-de-Grâce, Paris, France
Search for more papers by this authorCorresponding Author
Sébastien Banzet MD, PhD
Ecole du Val-de-Grâce, Paris, France
Institut de Recherche Biomédicale des Armées, Département Soutien Médico-Chirurgical des Forces, 1 rue du lieutenant Raoul Batany, 92140 Clamart, France
INSERM U1197, Clamart, France
Correspondence to: S. Banzet; e-mail: [email protected]Search for more papers by this authorNathalie Koulmann MD, PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Ecole du Val-de-Grâce, Paris, France
Search for more papers by this authorHélène Richard-Bulteau PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorBrigitte Crassous PharmD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorBernard Serrurier PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorMarielle Pasdeloup MSc
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Search for more papers by this authorXavier Bigard MD, PhD
Institut de Recherche Biomédicale des Armées, Département Environnements Opérationnels, Bretigny-Sur-Orge, France
Ecole du Val-de-Grâce, Paris, France
Search for more papers by this authorCorresponding Author
Sébastien Banzet MD, PhD
Ecole du Val-de-Grâce, Paris, France
Institut de Recherche Biomédicale des Armées, Département Soutien Médico-Chirurgical des Forces, 1 rue du lieutenant Raoul Batany, 92140 Clamart, France
INSERM U1197, Clamart, France
Correspondence to: S. Banzet; e-mail: [email protected]Search for more papers by this authorABSTRACT
Introduction: As skeletal muscle mass recovery after extensive injury is improved by contractile activity, we explored whether concomitant exercise accelerates recovery of the contractile and metabolic phenotypes after muscle injury. Methods: After notexin-induced degeneration of a soleus muscle, Wistar rats were assigned to active (running exercise) or sedentary groups. Myosin heavy chains (MHC), metabolic enzymes, and calcineurin were studied during muscle regeneration at different time points. Results: The mature MHC profile recovered earlier in active rats (21 days after injury) than in sedentary rats (42 days). Calcineurin was higher in the active degenerated than in the sedentary degenerated muscles at day 14. Citrate synthase and total lactate dehydrogenase (LDH) activity decreased after injury and were similarly recovered in both active and sedentary groups at 14 or 42 days, respectively. H-LDH isozyme activity recovered earlier in the active rats. Conclusions: Exercise improved recovery of the slow/oxidative phenotype after soleus muscle injury. Muscle Nerve 55: 91–100, 2017
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