Effect of resistance ladder training on sparc expression in skeletal muscle of hindlimb immobilized rats
Jun Seok Son BS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorJang Hoe Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorHee-Jae Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorDong Hyun Yoon MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorJin-Soo Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorHan Sol Song BS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorCorresponding Author
Wook Song PhD
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Institute on Aging, Seoul National University, Seoul, Korea
Correspondence to: W. Song; e-mail: [email protected]Search for more papers by this authorJun Seok Son BS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorJang Hoe Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorHee-Jae Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorDong Hyun Yoon MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorJin-Soo Kim MS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorHan Sol Song BS
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Search for more papers by this authorCorresponding Author
Wook Song PhD
Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea
Institute on Aging, Seoul National University, Seoul, Korea
Correspondence to: W. Song; e-mail: [email protected]Search for more papers by this authorABSTRACT
Introduction
Secreted protein acidic and rich in cysteine (SPARC) is associated with skeletal muscle atrophy. Here we examined possibility that resistance training could regulate SPARC expression in muscle atrophy in an immobilized hindlimb model.
Methods
Sprague-Dawley rats underwent resistance ladder training and hindlimb immobilization. Cross sectional area and grip strength were measured. SPARC protein levels in the plantaris and soleus, and serum after exercise and immobilization were then analyzed.
Results
Resistance training decreased body weight (P < 0.001) and increased muscle quality (P < 0.001). In the plantaris, muscle atrophy (31.82%) and up-regulated SPARC expression (P < 0.05) after immobilization were alleviated by resistance training.
Conclusions
Resistance training led to suppression of SPARC expression in the plantaris and showed a pretraining effect in atrophied rat muscle. Thus, SPARC may play a pivotal role in muscle homeostasis. Muscle Nerve 53: 951–957, 2016
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