Rapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI
Jin Zhang
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Search for more papers by this authorLi Feng
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
Search for more papers by this authorRicardo Otazo
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
Search for more papers by this authorCorresponding Author
Sungheon Gene Kim
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Correspondence
Sungheon Gene Kim, Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, New York, NY 10016.
Email: [email protected]
Search for more papers by this authorJin Zhang
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Search for more papers by this authorLi Feng
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
Search for more papers by this authorRicardo Otazo
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
Search for more papers by this authorCorresponding Author
Sungheon Gene Kim
Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York
Correspondence
Sungheon Gene Kim, Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, New York, NY 10016.
Email: [email protected]
Search for more papers by this authorFunding information: National Institutes of Health; Grant numbers: R01CA160620, P41EB017183, and 5P30CA016087
Abstract
Purpose
To develop a rapid dynamic contrast-enhanced MRI method with high spatial and temporal resolution for small-animal imaging at 7 Tesla.
Methods
An ultra-short echo time (UTE) pulse sequence using a 3D golden-angle radial sampling was implemented to achieve isotropic spatial resolution with flexible temporal resolution. Continuously acquired radial spokes were grouped into subsets for image reconstruction using a multicoil compressed sensing approach (Golden-angle RAdial Sparse Parallel; GRASP). The proposed 3D-UTE-GRASP method with high temporal and spatial resolutions was tested using 7 mice with GL261 intracranial glioma models.
Results
Iterative reconstruction with different temporal resolutions and regularization factors λ showed that, in all cases, the cost function decreased to less than 2.5% of its starting value within 20 iterations. The difference between the time-intensity curves of 3D-UTE-GRASP and nonuniform fast Fourier transform (NUFFT) images was minimal when λ was 1% of the maximum signal intensity of the initial NUFFT images. The 3D isotropic images were used to generate pharmacokinetic parameter maps to show the detailed images of the tumor characteristics in 3D and also to show longitudinal changes during tumor growth.
Conclusion
This feasibility study demonstrated that the proposed 3D-UTE-GRASP method can be used for effective measurement of the 3D spatial heterogeneity of tumor pharmacokinetic parameters.
Supporting Information
| Filename | Description |
|---|---|
| mrm27357-sup-0001-SupInfo.docxWord document, 20.4 MB |
FIGURE S1 Numerical simulation using a 3D phantom. (a) Numerical phantom images in the mid-coronal/sagittal/axial planes. The first column shows the simulated reference images with Rician noise of SNR = 10. The second column shows the NUFFT images. The third column shows the 3D-UTE-GRASP images reconstructed with λ = 1% and T = 5 seconds. Yellow, blue, and red regions are the selected tumor, muscle, and vessel ROIs used for the curves shown in (b) and (c). In (b) and (c), red solid lines are for the true enhancement curves, green solid lines for the true enhancement curves added with Rician noise, black dash dot lines for the enhancement curves measured from the NUFFT images, and blue solid lines for those from the 3D-UTE-GRASP images. FIGURE S2 Comparison of signal enhancement ratio curves of the reference (red solid), NUFFT (black), and 3D-UTE-GRASP (blue) for Region #1 (a), Region #2 (b), Region #3 (c), and Region #4 (d). Mean (solid lines) and standard deviation (dashed lines) of the curves were estimated using a bootstrapping analysis in each region. Red lines are for the reference curves, black for NUFFT and blue for 3D-UTE-GRASP. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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