Variability of 4D flow parameters when subjected to changes in MRI acquisition parameters using a realistic thoracic aortic phantom
Cristian Montalba
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorJesus Urbina
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorJulio Sotelo
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorMarcelo E. Andia
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorCristian Tejos
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorPablo Irarrazaval
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorDaniel E. Hurtado
Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorIsrael Valverde
Hospital Virgen del Rocio, Universidad de Sevilla, Seville, Spain
Institute of Biomedicine of Seville, Universidad de Sevilla, Seville, Spain
Search for more papers by this authorCorresponding Author
Sergio Uribe
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Correspondence to: Sergio Uribe, Ph.D., Department of Radiology, School of Medicine and Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile. E-mail: [email protected].Search for more papers by this authorCristian Montalba
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorJesus Urbina
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorJulio Sotelo
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorMarcelo E. Andia
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorCristian Tejos
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorPablo Irarrazaval
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorDaniel E. Hurtado
Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
Search for more papers by this authorIsrael Valverde
Hospital Virgen del Rocio, Universidad de Sevilla, Seville, Spain
Institute of Biomedicine of Seville, Universidad de Sevilla, Seville, Spain
Search for more papers by this authorCorresponding Author
Sergio Uribe
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile
Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Correspondence to: Sergio Uribe, Ph.D., Department of Radiology, School of Medicine and Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile. E-mail: [email protected].Search for more papers by this authorThis research was conducted with the support of CONICYT - PIA - Anillo ACT1416, CONICYT FONDEF/I Concurso IDeA en dos etapas ID15I10284; FONDECYT 1141036, 1141201, and 1161448; and FONDECYT PostDoctorado 2017 3170737.
Abstract
Purpose
To assess the variability of peak flow, mean velocity, stroke volume, and wall shear stress measurements derived from 3D cine phase contrast (4D flow) sequences under different conditions of spatial and temporal resolutions.
Methods
We performed controlled experiments using a thoracic aortic phantom. The phantom was connected to a pulsatile flow pump, which simulated nine physiological conditions. For each condition, 4D flow data were acquired with different spatial and temporal resolutions. The 2D cine phase contrast and 4D flow data with the highest available spatio-temporal resolution were considered as a reference for comparison purposes.
Results
When comparing 4D flow acquisitions (spatial and temporal resolution of 2.0 × 2.0 × 2.0 mm3 and 40 ms, respectively) with 2D phase-contrast flow acquisitions, the underestimation of peak flow, mean velocity, and stroke volume were 10.5, 10 and 5%, respectively. However, the calculated wall shear stress showed an underestimation larger than 70% for the former acquisition, with respect to 4D flow, with spatial and temporal resolution of 1.0 × 1.0 × 1.0 mm3 and 20 ms, respectively.
Conclusions
Peak flow, mean velocity, and stroke volume from 4D flow data are more sensitive to changes of temporal than spatial resolution, as opposed to wall shear stress, which is more sensitive to changes in spatial resolution. Magn Reson Med 79:1882–1892, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Supporting Information
Additional Supporting Information may be found in the online version of this article.
| Filename | Description |
|---|---|
| mrm26834-sup-0001-supptables.docx25.5 KB | Table S1. Stroke Volume Measurements Prescribed in the Fluid Pump and Obtained With MRI (Difference in Percentage) Table S2. Mean and Standard Deviation of Peak Flow (mL/s), Mean Velocity (cm/s), and Stroke Volume (mL) of 2D and 4D Flow Data of the Different Studied Segments of the Aortic Phantom Table S3. Mean Percentage Error Between 2D Flow And 4D Flow Acquisitions for Peak Flow (mL/s), Mean Velocity (cm/s), and Stroke Volume (mL) of the Different Studied Segments of the Aortic Phantom Table S4. Mean and Standard Deviation of WSS (n/m2) of All 4D Flow Data at Different Regions of the Aorta |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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