Volume 65, Issue 3 pp. 812-822
Full Paper

Motion compensated generalized reconstruction for free-breathing dynamic contrast-enhanced MRI

M. Filipovic

M. Filipovic

IADI Lab, INSERM-U947, Nancy, France

Nancy-Universite, Nancy, France

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P.-A. Vuissoz

P.-A. Vuissoz

IADI Lab, INSERM-U947, Nancy, France

Nancy-Universite, Nancy, France

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A. Codreanu

A. Codreanu

Centre Hospitalier de Luxembourg, Luxembourg

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M. Claudon

M. Claudon

IADI Lab, INSERM-U947, Nancy, France

University Hospital Nancy, Nancy, France

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J. Felblinger

Corresponding Author

J. Felblinger

IADI Lab, INSERM-U947, Nancy, France

INSERM-CIT801, Nancy, France

IADI Laboratory, INSERM-U947, Tour Drouet, CHU de Brabois, rue du Morvan, 54511 Vandoeuvre-lès-Nancy, France===Search for more papers by this author
First published: 29 September 2010
Citations: 25

Abstract

The analysis of abdominal and thoracic dynamic contrast-enhanced MRI is often impaired by artifacts and misregistration caused by physiological motion. Breath-hold is too short to cover long acquisitions. A novel multipurpose reconstruction technique, entitled dynamic contrast-enhanced generalized reconstruction by inversion of coupled systems, is presented. It performs respiratory motion compensation in terms of both motion artefact correction and registration. It comprises motion modeling and contrast-change modeling. The method feeds on physiological signals and x-f space properties of dynamic series to invert a coupled system of linear equations. The unknowns solved for represent the parameters for a linear nonrigid motion model and the parameters for a linear contrast-change model based on B-splines. Performance is demonstrated on myocardial perfusion imaging, on six simulated data sets and six clinical exams. The main purpose consists in removing motion-induced errors from time–intensity curves, thus improving curve analysis and postprocessing in general. This method alleviates postprocessing difficulties in dynamic contrast-enhanced MRI and opens new possibilities for dynamic contrast-enhanced MRI analysis. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc.

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