Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: Comparison with computational fluid dynamics
Corresponding Author
Loic Boussel
Radiology Service, VA Medical Center, San Francisco, California
Department of Radiology, University of California, San Francisco, California
Department of Radiology, VA Medical Center, 4150 Clement Street, San Francisco 94121===Search for more papers by this authorVitaliy Rayz
Radiology Service, VA Medical Center, San Francisco, California
Search for more papers by this authorAlastair Martin
Department of Radiology, University of California, San Francisco, California
Search for more papers by this authorGabriel Acevedo-Bolton
Radiology Service, VA Medical Center, San Francisco, California
Search for more papers by this authorMichael T. Lawton
Department of Neurological Surgery, University of California, San Francisco, California
Search for more papers by this authorRandall Higashida
Department of Radiology, University of California, San Francisco, California
Department of Neurological Surgery, University of California, San Francisco, California
Department of Neurology, University of California, San Francisco, California
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California
Search for more papers by this authorWade S. Smith
Department of Neurology, University of California, San Francisco, California
Search for more papers by this authorWilliam L. Young
Department of Neurological Surgery, University of California, San Francisco, California
Department of Neurology, University of California, San Francisco, California
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California
Search for more papers by this authorDavid Saloner
Radiology Service, VA Medical Center, San Francisco, California
Department of Radiology, University of California, San Francisco, California
Search for more papers by this authorCorresponding Author
Loic Boussel
Radiology Service, VA Medical Center, San Francisco, California
Department of Radiology, University of California, San Francisco, California
Department of Radiology, VA Medical Center, 4150 Clement Street, San Francisco 94121===Search for more papers by this authorVitaliy Rayz
Radiology Service, VA Medical Center, San Francisco, California
Search for more papers by this authorAlastair Martin
Department of Radiology, University of California, San Francisco, California
Search for more papers by this authorGabriel Acevedo-Bolton
Radiology Service, VA Medical Center, San Francisco, California
Search for more papers by this authorMichael T. Lawton
Department of Neurological Surgery, University of California, San Francisco, California
Search for more papers by this authorRandall Higashida
Department of Radiology, University of California, San Francisco, California
Department of Neurological Surgery, University of California, San Francisco, California
Department of Neurology, University of California, San Francisco, California
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California
Search for more papers by this authorWade S. Smith
Department of Neurology, University of California, San Francisco, California
Search for more papers by this authorWilliam L. Young
Department of Neurological Surgery, University of California, San Francisco, California
Department of Neurology, University of California, San Francisco, California
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California
Search for more papers by this authorDavid Saloner
Radiology Service, VA Medical Center, San Francisco, California
Department of Radiology, University of California, San Francisco, California
Search for more papers by this authorAbstract
Evolution of intracranial aneurysms is known to be related to hemodynamic forces such as wall shear stress (WSS) and maximum shear stress (MSS). Estimation of these parameters can be performed using numerical simulations with computational fluid dynamics (CFD), but can also be directly measured with magnetic resonance imaging (MRI) using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). To study the accuracy of 7D-MRV in estimating these parameters in vivo, in comparison with CFD, 7D-MRV and patient-specific CFD modeling was performed for 3 patients who had intracranial aneurysms. Visual and quantitative analyses of the flow pattern and distribution of velocities, MSS, and WSS were performed using the two techniques. Spearman's coefficients of correlation between the two techniques were 0.56 for the velocity field, 0.48 for MSS, and 0.59 for WSS. Visual analysis and Bland–Altman plots showed good agreement for flow pattern and velocities but large discrepancies for MSS and WSS. These results indicate that 7D-MRV can be used in vivo to measure velocity flow fields and for estimating MSS and WSS. Currently, however, this method cannot accurately quantify the latter two parameters. Magn Reson Med 61:409–417, 2009. © 2009 Wiley-Liss, Inc.
REFERENCES
- 1 Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, Niessen WJ, Breteler MM, van der Lugt A. Incidental findings on brain MRI in the general population. N Engl J Med 2007; 357: 1821–1828.
- 2 Krex D, Schackert HK, Schackert G. Genesis of cerebral aneurysms—an update. Acta Neurochir (Wien) 2001; 143: 429–448.
- 3 Unruptured intracranial aneurysms—risk of rupture and risks of surgical intervention. N Engl J Med 1998; 339: 1725–1733.
- 4 Wiebers DO, Whisnant JP, Huston J III, Meissner I, Brown RD Jr, Piepgras DG, Forbes GS, Thielen K, Nichols D, O'Fallon WM, Peacock J, Jaeger L, Kassell NF, Kongable-Beckman GL, Torner JC. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003; 362: 103–110.
- 5 Nader-Sepahi A, Casimiro M, Sen J, Kitchen ND. Is aspect ratio a reliable predictor of intracranial aneurysm rupture? Neurosurgery 2004; 54: 1343–1347.
- 6 Meng H, Wang Z, Hoi Y, Gao L, Metaxa E, Swartz DD, Kolega J. Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 2007; 38: 1924–1931.
- 7 Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K, Morita A, Kirino T. Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke 2004; 35: 2500–2505.
- 8 Wurzinger LJ, Blasberg P, Schmid-Schonbein H. Towards a concept of thrombosis in accelerated flow: rheology, fluid dynamics, and biochemistry. Biorheology 1985; 22: 437–450.
- 9 Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999; 282: 2035–2042.
- 10 Jou LD, Quick CM, Young WL, Lawton MT, Higashida R, Martin A, Saloner D. Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. AJNR Am J Neuroradiol 2003; 24: 1804–1810.
- 11 Long Q, Xu XY, Collins MW, Griffith TM, Bourne M. The combination of magnetic resonance angiography and computational fluid dynamics: a critical review. Crit Rev Biomed Eng 1998; 26: 227–274.
- 12 Cebral JR, Castro MA, Appanaboyina S, Putman CM, Millan D, Frangi AF. Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity. IEEE Trans Med Imaging 2005; 24: 457–467.
- 13 Steinman DA, Milner JS, Norley CJ, Lownie SP, Holdsworth DW. Image-based computational simulation of flow dynamics in a giant intracranial aneurysm. AJNR Am J Neuroradiol 2003; 24: 559–566.
- 14 Wigstrom L, Sjoqvist L, Wranne B. Temporally resolved 3D phase-contrast imaging. Magn Reson Med 1996; 36: 800–803.
- 15 Markl M, Chan FP, Alley MT, Wedding KL, Draney MT, Elkins CJ, Parker DW, Wicker R, Taylor CA, Herfkens RJ, Pelc NJ. Time-resolved three-dimensional phase-contrast MRI. J Magn Reson Imaging 2003; 17: 499–506.
- 16 Markl M, Draney MT, Hope MD, Levin JM, Chan FP, Alley MT, Pelc NJ, Herfkens RJ. Time-resolved 3-dimensional velocity mapping in the thoracic aorta: visualization of 3-directional blood flow patterns in healthy volunteers and patients. J Comput Assist Tomogr 2004; 28: 459–468.
- 17 Hope TA, Markl M, Wigstrom L, Alley MT, Miller DC, Herfkens RJ. Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping. J Magn Reson Imaging 2007; 26: 1471–1479.
- 18 Tateshima S, Grinstead J, Sinha S, Nien YL, Murayama Y, Villablanca JP, Tanishita K, Vinuela F. Intraaneurysmal flow visualization by using phase-contrast magnetic resonance imaging: feasibility study based on a geometrically realistic in vitro aneurysm model. J Neurosurg 2004; 100: 1041–1048.
- 19 Hollnagel DI, Summers PE, Kollias SS, Poulikakos D. Laser Doppler velocimetry (LDV) and 3D phase-contrast magnetic resonance angiography (PC-MRA) velocity measurements: validation in an anatomically accurate cerebral artery aneurysm model with steady flow. J Magn Reson Imaging 2007; 26: 1493–1505.
- 20 Papathanasopoulou P, Zhao S, Kohler U, Robertson MB, Long Q, Hoskins P, Xu XY, Marshall I. MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions. J Magn Reson Imaging 2003; 17: 153–162.
- 21 Marshall I, Zhao S, Papathanasopoulou P, Hoskins P, Xu Y. MRI and CFD studies of pulsatile flow in healthy and stenosed carotid bifurcation models. J Biomech 2004; 37: 679–687.
- 22 Boussel L, Wintermark M, Martin A, Dispensa B, Vantijen R, Leach J, Rayz V, Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D. Monitoring serial change in the lumen and outer wall of vertebrobasilar aneurysms. AJNR Am J Neuroradiol 2008; 29: 259–264.
- 23 Rayz V, Boussel L, Acevedo-Bolton G, Martin A, Young WL, Lawton M, Higashida R, Saloner D. Numerical simulations of flow in cerebral aneurysms comparison of CFD results and in vivo MRI measurements. J Biomech Eng 2008; 130.
- 24 Humphrey JD, Na S. Elastodynamics and arterial wall stress. Ann Biomed Eng 2002; 30: 509–523.
- 25 Kohler U, Marshall I, Robertson MB, Long Q, Xu XY, Hoskins PR. MRI measurement of wall shear stress vectors in bifurcation models and comparison with CFD predictions. J Magn Reson Imaging 2001; 14: 563–573.
- 26 Munson BR YD, Okiishi TH. Fundamentals of fluid mechanics. New York: John Wiley; 1990. p 18–22.
- 27 Ahn S, Shin D, Tateshima S, Tanishita K, Vinuela F, Sinha S. Fluid-induced wall shear stress in anthropomorphic brain aneurysm models: MR phase-contrast study at 3 T. J Magn Reson Imaging 2007; 25: 1120–1130.
- 28 Botnar R, Rappitsch G, Scheidegger MB, Liepsch D, Perktold K, Boesiger P. Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulations and in vitro MRI measurements. J Biomech 2000; 33: 137–144.
- 29 Gatehouse PD, Keegan J, Crowe LA, Masood S, Mohiaddin RH, Kreitner KF, Firmin DN. Applications of phase-contrast flow and velocity imaging in cardiovascular MRI. Eur Radiol 2005; 15: 2172–2184.
- 30 Lotz J, Meier C, Leppert A, Galanski M. Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation. Radiographics 2002; 22: 651–671.
- 31 Tateshima S, Tanishita K, Omura H, Villablanca JP, Vinuela F. Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm: in vitro study using longitudinal CT angiogram database. AJNR Am J Neuroradiol 2007; 28: 622–627.
- 32 Lotz J, Doker R, Noeske R, Schuttert M, Felix R, Galanski M, Gutberlet M, Meyer GP. In vitro validation of phase-contrast flow measurements at 3 T in comparison to 1.5 T: precision, accuracy, and signal-to-noise ratios. J Magn Reson Imaging 2005; 21: 604–610.
- 33 Meaney JF, Goyen M. Recent advances in contrast-enhanced magnetic resonance angiography. Eur Radiol 2007; 17: 2–6.
