FOLR1-stabilized β-catenin promotes laryngeal carcinoma progression through EGFR/AKT/GSK-3β pathway
Huawei Tuo
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorXuemei Li
Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorHaixia Du
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorMan Li
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorChenli Xu
Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorCorresponding Author
Zizhong Yu
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Correspondence Huzi Zhao, Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Zizhong Yu, Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Huzi Zhao
Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China
Correspondence Huzi Zhao, Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Zizhong Yu, Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Search for more papers by this authorHuawei Tuo
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorXuemei Li
Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorHaixia Du
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorMan Li
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorChenli Xu
Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China
Search for more papers by this authorCorresponding Author
Zizhong Yu
Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Correspondence Huzi Zhao, Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Zizhong Yu, Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Huzi Zhao
Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China
Correspondence Huzi Zhao, Department of Pathology, School of Basic Medical Science, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Zizhong Yu, Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Email: [email protected]
Search for more papers by this authorHuawei Tuo and Xuemei Li contributed equally to this work.
Abstract
Folate receptor 1 (FOLR1) is overexpressed in numerous epithelial malignancies; however, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear. In the present study, we demonstrated that FOLR1 messenger RNA and protein expression levels were higher in LSCC tissues than in the adjacent normal tissues. Additionally, FOLR1 promoted the proliferation and migration of LSCC cells, whereas small interfering RNA-mediated knockdown of β-catenin abolished these effects. Moreover, FOLR1 stabilizes β-catenin by inhibiting its ubiquitination and degradation. Furthermore, blocking the interaction between epidermal growth factor receptor (EGFR) and the EGFR/AKT/glycogen synthase (GSK)3β signaling axis both abolished FOLR1's effects on the expression and nuclear aggregation of β-catenin. In summary, our work reveals a novel mode in which FOLR1 promotes the proliferation and migration of LSCC by enhancing the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| mc23634-sup-0001-Revision_Supplementary_Material.docx1 MB | Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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