Calcium Silicate Whiskers-Enforced Poly(Ether-Ether-Ketone) Composites with Improved Mechanical Properties and Biological Activities for Bearing Bone Reconstruction
Jin Wang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorJie Lei
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China
Search for more papers by this authorYanru Hu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorLihui Meng
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorWenchao Li
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorFang Zhu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorBing Xie
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorCorresponding Author
Youfa Wang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Cao Yang
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Qingzhi Wu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorJin Wang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorJie Lei
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China
Search for more papers by this authorYanru Hu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorLihui Meng
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorWenchao Li
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorFang Zhu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorBing Xie
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
Search for more papers by this authorCorresponding Author
Youfa Wang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Cao Yang
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Qingzhi Wu
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Poly (ether-ether-ketone) (PEEK) displays promising potential application in bone tissue repair and orthopedic surgery due to its good biocompatibility and chemical stability. However, the bio-inertness and poor mechanical strength of PEEK greatly limit its application in load-bearing bones. In this study, calcium silicate whiskers (CSws) are synthesized and then compounded with PEEK to fabricate the PEEK/CSw composites with excellent mechanical properties, biological activity. Compared with PEEK, the PEEK/CSw composites exhibited higher hydrophilicity and ability to deposit hydroxyapatite on the surface. CSws are evenly dispersed in the PEEK matrix at 10 wt% content and the mechanical strength of the PEEK/CSw composite is ≈96.9 ± 2.4 MPa, 136.3 ± 2.4 MPa, and 266.0 ± 3.2 MPa, corresponding to tensile strength, compressive strength, and bending strength, respectively, which is 20%, 18%, and 52% higher than that of pure PEEK. The composites improve the adhesion, proliferation, and osteogenic differentiation of BMSCs. Furthermore, PEEK/CSw composite remarkably improves bone formation and osteointegration, which has higher bone repair capacity than PEEK. These results demonstrate that the PEEK/CSw scaffolds display superior abilities to integrate with the host bone and promising potential in the field of load bearing bone repair.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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References
- 1a) A. Mantovani, S. K. Biswas, M. R. Galdiero, A. Sica, M. Locati, J. Pathol. 2013, 229, 176; b) H.-W. Kang, S. J. Lee, I. K. Ko, C. Kengla, J. J. Yoo, A. Atala, Nat. Biotechnol. 2016, 34, 312; c) A. R. Amini, C. T. Laurencin, S. P. Nukavarapu, Crit. Rev. Biomed. Eng. 2012, 40, 363.
- 2a) C. Z. Gao, Z. L. Wang, Z. X. Jiao, Z. X. Wu, M. Guo, Y. Wang, J. G. Liu, P. B. Zhang, Mater. Des. 2021, 205, 14; b) B. I. Oladapo, S. A. Zahedi, S. O. Ismail, F. T. Omigbodun, Colloids Surf., B 2021, 203, 9.
- 3a) X. Gu, X. Sun, Y. Sun, J. Wang, Y. Liu, K. Yu, Y. Wang, Y. Zhou, Front. Bioeng. Biotechnol. 2021, 8, 15; b) T. Wan, Z. Jiao, M. Guo, Z. Wang, Y. Wan, K. Lin, Q. Liu, P. Zhang, Bioact. Mater. 2020, 5, 1004; c) T. Wei, J. Wang, X. Yu, Y. Wang, Q. Wu, C. Chen, RSC Adv. 2019, 9, 34642.
- 4a) D. Yu, X. Lei, H. Zhu, J. Zhejiang Univ., Sci., B 2022, 23, 189; b) H. Ma, A. Suonan, J. Zhou, Q. Yuan, L. Liu, X. Zhao, X. Lou, C. Yang, D. Li, Y.-G. Zhang, Arabian J. Chem. 2021, 14, 102977; c) X. Han, W. Gao, Z. Zhou, S. Yang, J. Wang, R. Shi, Y. Li, J. Jiao, Y. Qi, J. Zhao, Colloids Surf., B 2022, 215, 112492; d) J. Wang, Y. Wang, Q. Wu, J. Wuhan Univ.f Technol., Mater. Sci. Ed. 2021, 36, 766.
- 5a) C. Chen, L. Meng, Y. Hu, Z. Su, T. Zhang, Z. Ouyang, W. Li, J. Wan, Q. Wu, J. Mech. Behav. Biomed. Mater. 2021, 124, 104811; b) M. He, Y. Huang, H. Xu, G. Feng, L. Liu, Y. Li, D. Sun, L. Zhang, Acta Biomater. 2021, 129, 18; c) N. Taymour, A. E. Fahmy, M. A. H. Gepreel, S. Kandil, A. A. El-Fattah, Polymers 2022, 14, 1632.
- 6S. Verma, N. Sharma, S. Kango, S. Sharma, Eur. Polym. J. 2021, 147, 110295.
- 7a) S. Sathishkumar, P. Chakraborti, P. Jawahar, Polym.-Plast. Technol. Mater. 2022, 61, 1367; b) Y. Li, H. Jia, X. Cui, W. Qin, S. Qin, Y. Wu, M. Bai, X. Liu, F. Feng, J. Ma, Y. Li, Appl. Surf. Sci. 2022, 575, 151774.
- 8X. Yu, S. Yao, C. Chen, J. Wang, Y. Li, Y. Wang, A. Khademhosseini, J. Wan, Q. Wu, ACS Omega 2020, 5, 29398.
- 9C. Liang, X. Xiong, R. Cui, Y. Hong, X. Liu, G. Zhao, L. Ye, S. Qu, J. Bionic Eng. 2021, 18, 927.
- 10J. Zheng, E. Dong, J. Kang, C. Sun, C. Liu, L. Wang, D. Li, Polymers 2021, 13, 2547.
- 11L.-L. Wang, X. Dong, X.-R. Wang, G.-Y. Zhu, H.-Q. Li, D.-J. Wang, Chin. J. Polym. Sci. 2016, 34, 991.
- 12a) J. Singh, S. S. Chatha, H. Singh, Prog. Biomater. 2022, 11, 95; b) M. Andrei, R. P. Vacaru, A. Coricovac, R. Ilinca, A. C. Didilescu, I. Demetrescu, Molecules 2021, 26, 28.
- 13C. Y. Wang, Y. C. Chiu, A. K. X. Lee, Y. A. Lin, P. Y. Lin, M. Y. Shie, Biomedicines 2021, 9, 18.
- 14X. Feng, L. Ma, H. Liang, X. Liu, J. Lei, W. Li, K. Wang, Y. Song, B. Wang, G. Li, S. Li, C. Yang, ACS Omega 2020, 5, 26655.
- 15C. Shuai, G. Liu, Y. Yang, F. Qi, S. Peng, W. Yang, C. He, G. Wang, G. Qian, Nano Energy 2020, 74, 104825.
- 16M. Li, J. Bai, H. Tao, L. Hao, W. Yin, X. Ren, A. Gao, N. Li, M. Wang, S. Fang, Y. Xu, L. Chen, H. Yang, H. Wang, G. Pan, D. Geng, Bioact. Mater. 2022, 8, 309.
- 17I. Kovrlija, J. Locs, D. Loca, Acta Biomater. 2021, 135, 27.
- 18a) S. Maeno, Y. Niki, H. Matsumoto, H. Morioka, T. Yatabe, A. Funayama, Y. Toyama, T. Taguchi, J. Tanaka, Biomaterials 2005, 26, 4847; b) C. Wu, J. Chang, S. Ni, J. Wang, J. Biomed. Mater. Res., Part A 2006, 76A, 73.
- 19S. Yamamoto, L. Han, Y. Noiri, T. Okiji, Int. Endod. J. 2017, 50, e73.
- 20J. Ge, F. Wang, Z. Xu, X. Shen, C. Gao, D. Wang, G. Hu, J. Gu, T. Tang, J. Wei, J. Mater. Chem. B 2020, 8, 2618.
- 21a) S. Midha, K. G. Jain, N. Bhaskar, A. Kaur, S. Rawat, S. Giri, B. Basu, S. Mohanty, Stem Cells Transl. Med. 2021, 10, 303; b) C. Zhao, P. Qiu, M. Li, K. Liang, Z. Tang, P. Chen, J. Zhang, S. Fan, X. Lin, Mater. Today Bio 2021, 12, 100142; c) G. Hong, M. Liao, T. Wu, Q. Zhou, H. Xie, C. Chen, Appl. Surf. Sci. 2021, 570, 151144; d) P. Mullick, G. Das, R. Aiyagari, J. Colloid Interface Sci. 2022, 608, 2298.
- 22a) V. G. Varanasi, J. B. Owyoung, E. Saiz, S. J. Marshall, G. W. Marshall, P. M. Loomer, J. Biomed. Mater. Res., Part A 2011, 98A, 177;
b) L. Xia, N. Zhang, X. Wang, Y. Zhou, L. Mao, J. Liu, X. Jiang, Z. Zhang, J. Chang, K. Lin, B. Fang, J. Mater. Chem. B 2016, 4, 3313;
c) H. Lan, M. Zhang, X. Chen, Z. Huang, G. Yin, Smart Mater. Med. 2022, 3, 94;
10.1016/j.smaim.2021.09.002 Google Scholard) F. Hou, W. Jiang, Y. Zhang, J. Tang, D. Li, B. Zhao, L. Wang, Y. Gu, W. Cui, L. Chen, Chem. Eng. J. 2022, 427, 132000; e) W.-Y. Lai, Y.-J. Chen, A. K.-X. Lee, Y.-H. Lin, Y.-W. Liu, M.-Y. Shie, Biomedicines 2021, 9, 712.
- 23M.-H. Kim, M.-K. Choi, Biol. Trace Elem. Res. 2021, 199, 258.
- 24C.-T. Wu, J. Chang, J. Inorg. Mater. 2013, 28, 29.
- 25S. Vermeulen, Z. Tahmasebi Birgani, P. Habibovic, Biomaterials 2022, 283, 121431.
- 26J. Fu, X. Liu, L. Tan, Z. Cui, Y. Zheng, Y. Liang, Z. Li, S. Zhu, K. W. K. Yeung, X. Feng, X. Wang, S. Wu, ACS Nano 2019, 13, 13581.
- 27M. T. Tavares, M. B. Oliveira, J. O. F. Mano, J. P. S. Farinha, C. Baleizão, Mater. Sci. Eng., C 2020, 107, 110348.
- 28a) C. Wang, K. Lin, J. Chang, J. Sun, Biomaterials 2013, 34, 64; b) R. M. Sabino, J. V. Rau, A. De Bonis, A. De Stefanis, M. Curcio, R. Teghil, K. C. Popat, Appl. Surf. Sci. 2021, 570, 151163; c) X. He, X. Zhang, J. Li, R. Hang, X. Huang, X. Yao, L. Qin, B. Tang, J. Mater. Chem. B 2018, 6, 5100.
