A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy
Songhee Jeong
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
These authors contributed equally to this work.Search for more papers by this authorWooram Park
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
These authors contributed equally to this work.Search for more papers by this authorChung-Sung Lee
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
Search for more papers by this authorCorresponding Author
Kun Na
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
Search for more papers by this authorSonghee Jeong
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
These authors contributed equally to this work.Search for more papers by this authorWooram Park
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
These authors contributed equally to this work.Search for more papers by this authorChung-Sung Lee
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
Search for more papers by this authorCorresponding Author
Kun Na
Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi Do, 420-743 Korea
Search for more papers by this authorAbstract
Herein, a cancer-recognizing polymeric photosensitizer (CRPP) was demonstrated not only for high water solubility but also for pH-responsive targeted photodynamic cancer therapy. The synthesized CRPP exhibited high water solubility and the pH-dependent charge-switching property. From an in vitro cellular internalization study with HCT-116 human colon cancer cells, significantly enhanced cellular uptake as detected for CRPP at pH 6.5 compared to the cellular uptake of CRPP at pH 7.4, which led to enhanced cytotoxicity in the cancer cells. Finally, the CRPP was found to exhibit high tumor-targeting efficacy in an in vivo tumor model and was finally excreted through the renal route.
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| mabi201400361-sm-0001-SuppFig-S1.doc74 KB |
Figure S1: GPC curves and analysis of mPEG-poly(Bz-L-Asp) and mPEG-poly(Bz-L-Asp)-Ce6. Figure S2: The regression curve obtained by plotting the absorbance against the concentration of the standard Ce6 (λ = 670 nm). |
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