Volume 127, Issue 7 pp. E212-E218

Facial Plastics and Reconstructive Surgery

Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis

Benjamin A. Taylor MD,

Benjamin A. Taylor MD

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia

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Michael Bezuhly MD, MSc,

Michael Bezuhly MD, MSc

Department of Surgery, IWK Health Centre, Halifax, Nova Scotia

Division of Plastic and Reconstructive Surgery, Dalhousie University, Halifax, Nova Scotia

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Matthew Brace MD, MSc,

Matthew Brace MD, MSc

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada

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Michael Carter MD, PhD,

Michael Carter MD, PhD

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada

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Paul Hong MD, MSc,

Corresponding Author

Paul Hong MD, MSc

[email protected]

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia

Department of Surgery, IWK Health Centre, Halifax, Nova Scotia

Send correspondence to Dr. Paul Hong, IWK Health Centre, 5850/5980 University Avenue, P.O. Box 9700, Halifax, Nova Scotia B3K 6R8, Canada. E-mail: [email protected]Search for more papers by this author

Benjamin A. Taylor MD,

Benjamin A. Taylor MD

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia

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Michael Bezuhly MD, MSc,

Michael Bezuhly MD, MSc

Department of Surgery, IWK Health Centre, Halifax, Nova Scotia

Division of Plastic and Reconstructive Surgery, Dalhousie University, Halifax, Nova Scotia

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Matthew Brace MD, MSc,

Matthew Brace MD, MSc

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada

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Michael Carter MD, PhD,

Michael Carter MD, PhD

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada

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Paul Hong MD, MSc,

Corresponding Author

Paul Hong MD, MSc

[email protected]

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia

Department of Surgery, IWK Health Centre, Halifax, Nova Scotia

First published: 09 May 2017

https://doi.org/10.1002/lary.26623

Citations: 10

This study was supported by a research grant from the Dalhousie University Department of Surgery awarded to p.h. and m.bezuhly.

The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

Mandibular distraction osteogenesis (MDO) involves a lengthy consolidation phase where complications can occur. Strontium is an element that has been shown to improve bone healing. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model.

Study Design

Prospective animal model study.

Methods

Custom-made MDO devices were placed on 20 New Zealand White rabbits. After a 7-day latency period, distraction was performed at 1 mm/day for 5 days. The study group rabbits (n = 10) received oral strontium citrate; the other 10 rabbits served as controls. Mandibles were removed at the end of the consolidation period (4 weeks). Formation and healing of new bone were evaluated with microcomputed tomography, histology, and a three-point bending mechanical test.

Results

New bone formed in all animals, but the consolidation process was enhanced in rabbits that received strontium. The histological analysis showed that study group rabbits had more mature bone. Microcomputed tomographic images demonstrated significantly higher bone density for study group animals, and the three-point bending test results demonstrated that the maximum load of the study group specimens was significantly greater than that of the control group mandibles.

Conclusions

Strontium citrate improved the formation of new bone in the current rabbit model of MDO. The prolonged consolidation period may be shortened with strontium citrate, which may also have the potential to reduce complications.

Level of Evidence

NA Laryngoscope, 127:E212–E218, 2017

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Citing Literature

Volume127, Issue7

July 2017

Pages E212-E218

Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

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