Volume 38, Issue 1 pp. 149-155

Original Research

Transvaginal Ultrasound Shear Wave Elastography for the Evaluation of Benign Uterine Pathologies: A Prospective Pilot Study

Man Zhang MD, PhD,

Corresponding Author

Man Zhang MD, PhD

[email protected]

orcid.org/0000-0002-7153-4881

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Department of Radiology, University of Washington, Seattle, Washington

Address correspondence to Man Zhang, MD, PhD, Department of Radiology, University of Washington Medical Center, Box No. 357115, Seattle, WA 98195. E-mail: [email protected]Search for more papers by this author

Ashish P. Wasnik MD,

Ashish P. Wasnik MD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

William R. Masch MD,

William R. Masch MD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Jonathan M. Rubin MD, PhD,

Jonathan M. Rubin MD, PhD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Ruth C. Carlos MD, MS,

Ruth C. Carlos MD, MS

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

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Elisabeth H. Quint MD,

Elisabeth H. Quint MD

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

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Katherine E. Maturen MD, MS,

Katherine E. Maturen MD, MS

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Man Zhang MD, PhD,

Corresponding Author

Man Zhang MD, PhD

[email protected]

orcid.org/0000-0002-7153-4881

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Department of Radiology, University of Washington, Seattle, Washington

Ashish P. Wasnik MD,

Ashish P. Wasnik MD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

William R. Masch MD,

William R. Masch MD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Jonathan M. Rubin MD, PhD,

Jonathan M. Rubin MD, PhD

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Ruth C. Carlos MD, MS,

Ruth C. Carlos MD, MS

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Elisabeth H. Quint MD,

Elisabeth H. Quint MD

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

Search for more papers by this author

Katherine E. Maturen MD, MS,

Katherine E. Maturen MD, MS

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

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First published: 06 May 2018

https://doi.org/10.1002/jum.14676

Citations: 40

This study was completed with financial support from the Association of University Radiologists and General Electric through the AUR-GERRAF fellowship program (K.E.M.). The authors gratefully acknowledge the efforts of research team members James Pool, LaDonna Austin, and Tamara Harper, and ultrasound technologist Annica Johnson.

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Abstract

Objectives

This study evaluated the diagnostic performance of transvaginal ultrasound (TVUS) shear wave elastography (SWE) for evaluating uterine adenomyosis and leiomyomas.

Methods

Institutional Review Board approval was obtained for prospective enrollment of 34 premenopausal women with pelvic pain and/or bleeding between January 2015 and June 2016. TVUS SWE was performed with regions of interest in multiple uterine segments and shear wave velocities(SWVs) were recorded. Reference pelvic magnetic resonance examinations were performed and reviewed without access to the ultrasound results.

Results

Continuous variables were analyzed using means, t tests, and analysis of variance. Magnetic resonance imaging revealed adenomyosis in 6 women (12 uterine segments) and leiomyomas in 12 women (28 segments). On a per-patient basis, mean SWV in 16 women with no adenomyosis or leiomyoma was 4.3 ± 1.7 m/s, compared with 5.7 ± 2.3 m/s in 18 women with a magnetic resonance diagnosis of myometrial pathology (P < .0002; 95% confidence interval, −2.2, −0.6). On a per-segment basis, SWV in normal myometrium was 4.8 ± 1.9 m/s, compared with 4.9 ± 2.5 m/s in adenomyosis and 5.6 ± 2.5 m/s in leiomyoma (P = .34 by one-way analysis of variance). In pairwise comparison, SWV for adenomyosis and leiomyoma did not differ significantly (P = .40).

Conclusions

TVUS SWE did not distinguish adenomyosis from leiomyoma. However, our pilot study demonstrated that myometrial SWVs were higher in uteri with adenomyosis and leiomyomas than in uteri with myometrium with no abnormalities suggesting a potential role for SWE in treatment response assessment.

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Volume38, Issue1

January 2019

Pages 149-155

Transvaginal Ultrasound Shear Wave Elastography for the Evaluation of Benign Uterine Pathologies: A Prospective Pilot Study

Abstract

Objectives

Methods

Results

Conclusions

References

Citing Literature

References

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Transvaginal Ultrasound Shear Wave Elastography for the Evaluation of Benign Uterine Pathologies: A Prospective Pilot Study

Abstract

Objectives

Methods

Results

Conclusions

References

Citing Literature

References

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