Volume 131, Issue 7 pp. 1321-1328
RESEARCH ARTICLE

Household Exposure to Substance Abuse and the Risk of New Persistent Opioid Use After Cancer Surgery

Mujtaba Khalil

Mujtaba Khalil

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Selamawit Woldesenbet

Selamawit Woldesenbet

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Shreya Shaw

Shreya Shaw

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Shahzaib Zindani

Shahzaib Zindani

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Zayed Rashid

Zayed Rashid

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Abdullah Altaf

Abdullah Altaf

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Razeen Thammachack

Razeen Thammachack

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Syed Husain

Syed Husain

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

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Timothy M. Pawlik

Corresponding Author

Timothy M. Pawlik

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA

Correspondence: Timothy M. Pawlik ([email protected])

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First published: 13 January 2025
Citations: 1

ABSTRACT

Background

Household-level factors may also influence the risk of new persistent opioid use (NPOU). We sought to assess the risk of NPOU among individuals with household exposure to substance abuse.

Methods

Opioid-naïve individuals who underwent oncological procedures were identified using the IBM MarketScan database. Multivariable regression equations were used to assess the association between household exposure to substance abuse and NPOU.

Results

Among 10 557 individuals 4.9% (n = 520) had a family history of substance abuse. Patients with a family history of substance abuse were more likely to use opioids during the perioperative (85.0% vs. 78.8%) and postoperative periods (40.2% vs. 34.1%) (both p < 0.05). Moreover, perioperative (300 MME [IQR: 450–200] vs. 250 MME [IQR: 150–435]) and postoperative (525 MME [IQR: 1348–225] vs. 350 MME [IQR: 150–850]) opioid dose was also higher among patients with a family history of substance abuse (both p < 0.001). On multivariate analysis, patients with family history of substance abuse had 37% (OR 1.37, 95% CI 1.07–1.75) higher odds of NPOU.

Conclusion

Among opioid-naïve individuals undergoing oncological procedures, a family history of substance abuse is associated with NPOU. Patients should be screened for household-level factors before prescribing opioids for perioperative use.

Conflicts of Interest

The authors declare no conflicts of interest.

Data Availability Statement

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.