Volume 128, Issue 4 pp. 635-644
REVIEW ARTICLE

Anorectal melanoma

Suzanne Fastner BS

Suzanne Fastner BS

Huntsman Cancer Institute, Salt Lake City, Utah, USA

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Tina J. Hieken MD

Tina J. Hieken MD

Department of Surgery, Division of Breast and Melanoma Surgical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Robert R. McWilliams MD

Robert R. McWilliams MD

Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA

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John Hyngstrom MD

Corresponding Author

John Hyngstrom MD

Huntsman Cancer Institute, Salt Lake City, Utah, USA

Department of Surgery, Division of Surgical Oncology, University of Utah, Salt Lake City, Utah, USA

Correspondence John Hyngstrom, MD, Huntsman Cancer Hospital, University of Utah Health, 1950 Cir of Hope Dr, Salt Lake City, UT 84132, USA.

Email: [email protected]

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First published: 03 July 2023

Abstract

Anorectal melanoma is an aggressive mucosal melanoma subtype with a poor prognosis. Although recent advancements have been seen for cutaneous melanoma, the optimal treatment paradigm for management of anorectal melanoma is evolving. In this review, we highlight differences in the pathogenesis of mucosal versus cutaneous melanoma, new concepts of staging for mucosal melanoma, updates to surgical management of anorectal melanoma, and current data for adjuvant radiation and systemic therapy in this unique patient population.

DATA AVAILABILITY STATEMENT

Data sharing is not applicable to this article as no primary data were created or analyzed in this study.

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