Signet ring cell carcinoma of resectable metastatic colorectal cancer has rare surgical value
Jianfei Fu MD
Department of Oncology, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Search for more papers by this authorLunpo Wu MD
Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, China
Search for more papers by this authorMengjie Jiang MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorYinuo Tan MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorDan Li MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorFei Chen MD
Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, China
Search for more papers by this authorTing Jiang MD
Department of Nuclear Medicine, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Search for more papers by this authorCorresponding Author
Jinlin Du MD
Department of Colorectal Surgery, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Correspondence to: Jinlin Du, MD, Department of Colorectal Surgery, Zhejiang University Jinhua Hospital, 351 Mingyue Road, Jinhua 321000, Zhejiang Province, China. Fax: +86-579-82552856. E-mail: [email protected]
Search for more papers by this authorJianfei Fu MD
Department of Oncology, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Search for more papers by this authorLunpo Wu MD
Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, China
Search for more papers by this authorMengjie Jiang MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorYinuo Tan MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorDan Li MD
Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Search for more papers by this authorFei Chen MD
Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, China
Search for more papers by this authorTing Jiang MD
Department of Nuclear Medicine, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Search for more papers by this authorCorresponding Author
Jinlin Du MD
Department of Colorectal Surgery, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang Province, China
Correspondence to: Jinlin Du, MD, Department of Colorectal Surgery, Zhejiang University Jinhua Hospital, 351 Mingyue Road, Jinhua 321000, Zhejiang Province, China. Fax: +86-579-82552856. E-mail: [email protected]
Search for more papers by this authorAbstract
Background and Objectives
Signet ring cell carcinoma (SRCC) is a uniquely separated subgroup in metastatic colorectal cancer (mCRC). The aims are to investigate the value of resection in patients with resectable metastatic signet ring cell colorectal cancer.
Methods
Patients with mCRC who underwent resection in Surveillance, Epidemiology, and End Results database during 1998–2010 were retrospectively analyzed. Kaplan–Meier and COX models were used to analyze the differences in the survival. Logistic regression models were used to evaluate the relationship between SRCC and other clinicopathological factors.
Results
Among the 3,568 patients, 94 (2.63%) patients had SRCC. The median survival time of patients with SRCC and non-SRCC were 17 and 29 months, respectively (P < 0.001). Multivariate analysis indicated that SRCC was an independent prognostic factor for poor overall survival. Logistic regression model based on variables identified by univariate analysis indicated that younger age (≤50 years old) (P = 0.005), female (P < 0.001), location in colon (P = 0.012), and N positive status (P = 0.003) were independent variables correlated with the SRCC subgroup. SRCC had a dramatically higher invalid surgical outcome rate than non-SRCC (P = 0.001).
Conclusion
SRCC patients might benefit little from the resection of primary and metastatic lesions with a high rate of undergoing invalid operations. J. Surg. Oncol. 2016;114:1004–1008. © 2016 Wiley Periodicals, Inc.
Supporting Information
Additional supporting information may be found in the online version of this article at the publisher's web-site.
| Filename | Description |
|---|---|
| jso24437-sup-0001-SupFig-S1.tif19 MB | Supplemental Figure S1 |
| jso24437-sup-0002-SupData-S1.docx21.8 KB | Supplemental Data 1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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