Volume 109, Issue 3 pp. 239-244

Research Article

Palliative surgery in patients with unresectable colorectal liver metastases: a propensity score matching analysis

Yong Sik Yoon MD,

Yong Sik Yoon MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Chan Wook Kim MD,

Chan Wook Kim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Seok-Byung Lim MD,

Seok-Byung Lim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Chang Sik Yu MD,

Chang Sik Yu MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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So Yeon Kim MD,

So Yeon Kim MD

Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Tae Won Kim MD,

Tae Won Kim MD

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Min-Ju Kim BS,

Min-Ju Kim BS

Departments of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Jin Cheon Kim MD,

Corresponding Author

Jin Cheon Kim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Correspondence to: Dr. Jin Cheon Kim, MD, Department of Surgery, University of Ulsan College of Medicine, 86 Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea. Fax: +82-247-490-27.

E-mail: [email protected]

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Yong Sik Yoon MD,

Yong Sik Yoon MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Chan Wook Kim MD,

Chan Wook Kim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Seok-Byung Lim MD,

Seok-Byung Lim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Chang Sik Yu MD,

Chang Sik Yu MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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So Yeon Kim MD,

So Yeon Kim MD

Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Tae Won Kim MD,

Tae Won Kim MD

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Min-Ju Kim BS,

Min-Ju Kim BS

Departments of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

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Jin Cheon Kim MD,

Corresponding Author

Jin Cheon Kim MD

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Correspondence to: Dr. Jin Cheon Kim, MD, Department of Surgery, University of Ulsan College of Medicine, 86 Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea. Fax: +82-247-490-27.

E-mail: [email protected]

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First published: 25 October 2013

https://doi.org/10.1002/jso.23480

Citations: 23

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ABSTRACT

Background and Objectives

The current study was primarily intended to determine the best surgical treatment for patients with unresectable liver metastatic colorectal cancer (CRC). In addition, we assessed whether the improvement in survival resulting from palliative resection (PR) of the primary tumor was a function of the extent of liver metastasis.

Methods

The demographics, tumor characteristics, and survival outcomes of 261 patients who underwent palliative surgery for unresectable liver metastatic CRC were analyzed. A propensity-score model was used to compare the group of patients receiving PR and non-resection (NR).

Results

There were 195 PR patients and 66 NR. The median survival of PR and NR patients was 21 months and 10 months, respectively (P < 0.001). In a Cox multivariate analysis of 51 propensity-score matched pairs, PR resulted in longer survival than NR (Hazard Ratio for NR 1.481; 95% confidence interval: 1.003–2.185; P = 0.048). The extent of liver metastasis only led to better survival of PR than NR patients among patients with limited liver metastasis not among those with extensive liver metastasis (P = 0.001).

Conclusions

PR appears to result in better survival than NR when the patient's overall condition permits an aggressive approach, especially in patients with limited liver metastases. J. Surg. Oncol. 2014 109:239–244. © 2013 Wiley Periodicals, Inc.

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Volume109, Issue3

March 1, 2014

Pages 239-244

Palliative surgery in patients with unresectable colorectal liver metastases: a propensity score matching analysis

ABSTRACT

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

Information

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Palliative surgery in patients with unresectable colorectal liver metastases: a propensity score matching analysis

ABSTRACT

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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