Volume 51, Issue 1 pp. 273-285

Original Research

Whole-tumor histogram analysis of monoexponential and advanced diffusion-weighted imaging for sinonasal malignant tumors: Correlations with histopathologic features

Zebin Xiao MD, PhD,

Zebin Xiao MD, PhD

Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, P.R. China

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Zuohua Tang MD, PhD,

Corresponding Author

Zuohua Tang MD, PhD

[email protected]

orcid.org/0000-0003-4687-5905

Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, P.R. China

Address reprint requests to: Z.T., Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, P.R. China. E-mail: [email protected] and G.Y., Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P.R. China. Email: [email protected]Search for more papers by this author

Jing Zhang BS,

Jing Zhang BS

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

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Guang Yang PhD,

Corresponding Author

Guang Yang PhD

[email protected]

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

Wenjiao Zeng PhD,

Wenjiao Zeng PhD

Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China

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Jianfeng Luo PhD,

Jianfeng Luo PhD

Department of Biostatistics, School of Public Health, Fudan University, Shanghai, P.R. China

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Yang Song BS,

Yang Song BS

orcid.org/0000-0001-7426-4496

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

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Zhongshuai Zhang PhD,

Zhongshuai Zhang PhD

Siemens Healthcare Ltd., Shanghai, P.R. China

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Zebin Xiao MD, PhD,

Zebin Xiao MD, PhD

Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, P.R. China

Search for more papers by this author

Zuohua Tang MD, PhD,

Corresponding Author

Zuohua Tang MD, PhD

[email protected]

orcid.org/0000-0003-4687-5905

Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, P.R. China

Jing Zhang BS,

Jing Zhang BS

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

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Guang Yang PhD,

Corresponding Author

Guang Yang PhD

[email protected]

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

Wenjiao Zeng PhD,

Wenjiao Zeng PhD

Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China

Search for more papers by this author

Jianfeng Luo PhD,

Jianfeng Luo PhD

Department of Biostatistics, School of Public Health, Fudan University, Shanghai, P.R. China

Search for more papers by this author

Yang Song BS,

Yang Song BS

orcid.org/0000-0001-7426-4496

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, P.R. China

Search for more papers by this author

Zhongshuai Zhang PhD,

Zhongshuai Zhang PhD

Siemens Healthcare Ltd., Shanghai, P.R. China

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First published: 04 July 2019

https://doi.org/10.1002/jmri.26857

Citations: 20

The first two authors contributed equally to this work.

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Abstract

Background

The histopathological basis of monoexponential diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) in the characterization of sinonasal malignant tumors is still unclear.

Purpose

To explore the correlations of histogram metrics from monoexponential DWI, IVIM, and DKI with histopathologic features in sinonasal malignant tumors.

Study Type

Retrospective.

Subjects

In all, 76 patients with sinonasal malignant tumors.

Field Strength/Sequence

Fourteen different b values (b = 0, 50, 100, 150, 200, 250, 300, 350, 400, 800, 1000, 1500, 2000, and 2500 sec/mm²) were used to perform different DWI models at 3.0T.

Assessment

The whole-tumor histogram metrics were calculated on the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), diffusion kurtosis (K), and diffusion coefficient (Dk) maps. Histopathologic features, including nuclear, cytoplasmic, cellular, stromal fractions, and the nuclear-to-cytoplasmic (N/C) ratio, were measured.

Statistical Tests

Spearman correlations and stepwise multiple linear regression analyses were performed to determine the correlations between histogram metrics and histopathologic features.

Results

ADC, Dk, and f histogram metrics showed significant correlations with investigated histopathologic features; D and K histogram metrics were significantly correlated with cellular, stromal, and nuclear fractions (all P < 0.05). Significant correlations between the 75th percentile of D and cytoplasmic fraction and between the kurtosis of K and the N/C ratio were observed (P < 0.05). The skewness of Dk, K, and the 75th percentile of D were independently associated with cellular and nuclear fractions; the skewness of Dk and K were independently associated with stromal fraction (P < 0.05).

Data Conclusion

Monoexponential and advanced DWI histogram parameters were significantly correlated with histopathologic features in sinonasal malignancies.

Level of Evidence: 3

Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:273–285.

Conflict of Interest

None declared.

Supporting Information

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Citing Literature

Volume51, Issue1

January 2020

Pages 273-285

Filename	Description
jmri26857-sup-0001-TableS1.docWord document, 180.5 KB	Supplemental Table 1 Correlations between Quantitative MR Parameters (ADC, D, D*, f, Dk and K) with Histopathological Features in Squamous Cell Carcinomas
jmri26857-sup-0002-AppendixS1.docWord document, 44 KB	AppendixE1: Monoexponential and advanced DWI Parametric Maps Acquisition

Whole-tumor histogram analysis of monoexponential and advanced diffusion-weighted imaging for sinonasal malignant tumors: Correlations with histopathologic features

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Conflict of Interest

Supporting Information

References

Citing Literature

References

Information

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Whole-tumor histogram analysis of monoexponential and advanced diffusion-weighted imaging for sinonasal malignant tumors: Correlations with histopathologic features

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Conflict of Interest

Supporting Information

References

Citing Literature

References

Related

Information