Original Research

Can texture analysis in ultrashort echo-time MRI distinguish primary graft dysfunction from acute rejection in lung transplants? A multidimensional assessment in a mouse model

Corresponding Author

André Euler MD

[email protected]

orcid.org/0000-0001-5019-4585

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

Address reprint requests to: A.E., Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Ramistrasse 100, CH – 8091 Zurich, Switzerland. E-mail: [email protected]Search for more papers by this author

Christian Blüthgen MS, MD,

Christian Blüthgen MS, MD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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Moritz C. Wurnig MD,

Moritz C. Wurnig MD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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Wolfgang Jungraithmayr MD,

Wolfgang Jungraithmayr MD

Department of Thoracic Surgery, University Hospital Rostock, Rostock, Germany

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Andreas Boss MD, PhD,

Andreas Boss MD, PhD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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André Euler MD,

Corresponding Author

André Euler MD

[email protected]

orcid.org/0000-0001-5019-4585

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

Christian Blüthgen MS, MD,

Christian Blüthgen MS, MD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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Moritz C. Wurnig MD,

Moritz C. Wurnig MD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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Wolfgang Jungraithmayr MD,

Wolfgang Jungraithmayr MD

Department of Thoracic Surgery, University Hospital Rostock, Rostock, Germany

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Andreas Boss MD, PhD,

Andreas Boss MD, PhD

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

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First published: 31 May 2019

https://doi.org/10.1002/jmri.26817

Citations: 3

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Abstract

Background

Differentiation of early postoperative complications affects treatment options after lung transplantation.

Purpose

To assess if texture analysis in ultrashort echo-time (UTE) MRI allows distinction of primary graft dysfunction (PGD) from acute transplant rejection (ATR) in a mouse lung transplant model.

Study Type

Longitudinal.

Animal Model

Single left lung transplantation was performed in two cohorts of six mice (strain C57BL/6) receiving six syngeneic (strain C57BL/6) and six allogeneic lung transplants (strain BALB/c (H-2K^d)).

Field Strength/Sequence

4.7T small-animal MRI/eight different UTE sequences (echo times: 50–5000 μs) at three different postoperative timepoints (1, 3, and 7 days after transplantation).

Assessment

Nineteen different first- and higher-order texture features were computed on multiple axial slices for each combination of UTE and timepoint (24 setups) in each mouse. Texture features were compared for transplanted (graft) and contralateral native lungs between and within syngeneic and allogeneic cohorts. Histopathology served as a reference.

Statistical Tests

Nonparametric tests and correlation matrix analysis were used.

Results

Pathology revealed PGD in the syngeneic and ATR in the allogeneic cohort. Skewness and low-gray-level run-length features were significantly different between PGD and ATR for all investigated setups (P < 0.03). These features were significantly different between graft and native lung in ATR for most setups (minimum of 20/24 setups; all P < 0.05). The number of significantly different features between PGD and ATR increased with elapsing postoperative time. Differences in significant features were highest for an echo-time of 1500 μs.

Data Conclusion

Our findings suggest that texture analysis in UTE-MRI might be a tool for the differentiation of PGD and ATR in the early postoperative phase after lung transplantation.

Level of Evidence: 1

Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2020;51:108–116.

Supporting Information

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Citing Literature

Volume51, Issue1

January 2020

Pages 108-116

Filename	Description
jmri26817-sup-0001-FigureA1.tifTIFF image, 42.2 MB	Fig. A1 Graphs illustrate the absolute values and 95% confidence intervals of all 19 texture features for PGD (orange) and ATR (blue) for the three different postoperative time points (D1 = 1 day, D3 = 3 days; D7 = 7days) in the graft.
jmri26817-sup-0002-FigureA2.tifTIFF image, 42.4 MB	Fig. A2 Graphs illustrate the absolute values and 95% confidence intervals of all 19 texture features for PGD (orange) and ATR (blue) for the three different postoperative time points (D1 = 1 day, D3 = 3 days; D7 = 7days) in the native lung.
jmri26817-sup-0003-FigureB1.tifTIFF image, 3.7 MB	Fig. B1 Correlogram visualizing the correlation matrix for the native lung of the syngeneic cohort (PGD).
jmri26817-sup-0004-FigureB2.tifTIFF image, 3.7 MB	Fig. B2 Correlogram visualizing the correlation matrix for the graft of the allogeneic cohort (PGD).
jmri26817-sup-0005-FigureB3.tifTIFF image, 3.7 MB	Fig. B3 Correlogram visualizing the correlation matrix for the native lung of the allogeneic cohort (PGD).

Can texture analysis in ultrashort echo-time MRI distinguish primary graft dysfunction from acute rejection in lung transplants? A multidimensional assessment in a mouse model

Abstract

Background

Purpose

Study Type

Animal Model

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Supporting Information

References

Citing Literature

References

Information

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Can texture analysis in ultrashort echo-time MRI distinguish primary graft dysfunction from acute rejection in lung transplants? A multidimensional assessment in a mouse model

Abstract

Background

Purpose

Study Type

Animal Model

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Supporting Information

References

Citing Literature

References

Related

Information