Volume 51, Issue 2 pp. 514-523

Original Research

Increasing body mass index in an elderly cohort: Effects on the quantitative MR parameters of the brain

Melissa Schall PhD,

Melissa Schall PhD

orcid.org/0000-0001-7511-4668

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

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Elene Iordanishvili MD, PhD,

Elene Iordanishvili MD, PhD

orcid.org/0000-0001-5937-3790

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

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Jörg Mauler MD, PhD,

Jörg Mauler MD, PhD

orcid.org/0000-0003-4937-0355

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

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Ana-Maria Oros-Peusquens PhD,

Ana-Maria Oros-Peusquens PhD

orcid.org/0000-0002-8536-8044

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

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N. Jon Shah PhD,

Corresponding Author

N. Jon Shah PhD

[email protected]

orcid.org/0000-0002-8151-6169

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

Research Centre Jülich, Institute of Neuroscience and Medicine 11 (INM-11), Jülich, Germany

Jülich Aachen Research Alliance (JARA-BRAIN) — Translational Medicine, Aachen, Germany

Department of Neurology of the RWTH Aachen University, Aachen, Germany

Address reprint requests to: N.J.S., Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52425 Jülich, Germany. E-mail: [email protected]Search for more papers by this author

Melissa Schall PhD,

Melissa Schall PhD

orcid.org/0000-0001-7511-4668

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

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Elene Iordanishvili MD, PhD,

Elene Iordanishvili MD, PhD

orcid.org/0000-0001-5937-3790

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

Search for more papers by this author

Jörg Mauler MD, PhD,

Jörg Mauler MD, PhD

orcid.org/0000-0003-4937-0355

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

Search for more papers by this author

Ana-Maria Oros-Peusquens PhD,

Ana-Maria Oros-Peusquens PhD

orcid.org/0000-0002-8536-8044

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

Search for more papers by this author

N. Jon Shah PhD,

Corresponding Author

N. Jon Shah PhD

[email protected]

orcid.org/0000-0002-8151-6169

Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany

Research Centre Jülich, Institute of Neuroscience and Medicine 11 (INM-11), Jülich, Germany

Jülich Aachen Research Alliance (JARA-BRAIN) — Translational Medicine, Aachen, Germany

Department of Neurology of the RWTH Aachen University, Aachen, Germany

Address reprint requests to: N.J.S., Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52425 Jülich, Germany. E-mail: [email protected]Search for more papers by this author

First published: 31 May 2019

https://doi.org/10.1002/jmri.26807

Citations: 6

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Abstract

Background

Body mass index (BMI) is increasing in a large number of elderly persons. This increase in BMI is known to put one at risk for many "diseases of aging," although less is known about how a change in BMI may affect the brains of the elderly.

Purpose

To investigate the relationship between BMI and quantitative water content, T₁, T₂*, and the semi-quantitative magnetization transfer ratio (MTR) of various structures in elderly brains.

Study Type

Cross-sectional.

Subjects

Forty-two adults (BMI range: 19.1–33.5 kg/m², age range: 58–80 years).

Field Strength

3T MRI (two multi-echo gradient echoes, actual flip angle imaging, magnetization prepared rapid gradient echo, fluid attenuated inversion recovery).

Assessment

The 3D two-point method was used to derive (semi-)quantitative parameters in global white (WM) and gray matter (GM) and their regions as defined by the Johns Hopkins University and the Montreal Neurological Institute atlases.

Statistical Tests

Multivariate linear regression with BMI as principal regressor, corrected for the additional regressors age, gender, and glycated hemoglobin. Spearman correlation between quantitative parameters of the regions showing significant changes and the lipid spectra / C-reactive protein (CRP). Voxel-based morphometry and analysis of covariance (ANCOVA) to explore changes in the GM volume.

Results

T₁ increased significantly (P < 0.05) in the frontal, temporal, and parietal cortices, while the bilateral corona radiata, right superior longitudinal fasciculus, as well as the corpus callosum showed significant changes in the WM regions. T₂* increased significantly in the global WM and left corona radiata. Changes in MTR and the free water content did not reach significance. No significant correlation between any quantitative parameter and the lipid spectra or CRP could be identified.

Data Conclusion

These results suggest that an elevated BMI predominantly affects T₁ in WM as well as GM structures in the elderly human brain.

Level of Evidence: 3

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2020;51:514–523.

Supporting Information

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Citing Literature

Volume51, Issue2

February 2020

Pages 514-523

Filename	Description
jmri26807-sup-0001-Supinfo.docxWord 2007 document , 46.1 KB	S1 Text Multivariate regression results including all ROIs (P > 0.05 and P < 0.05).
jmri26807-sup-0002-TableS1.pdfPDF document, 17.4 KB	S1 Table List of significant (P < 0.05) multiple linear regression results of the quantitative parameters.
jmri26807-sup-0003-TableS2.pdfPDF document, 25.9 KB	S2 Table Results of the correlation analysis between the quantitative parameters in ROIs, which showed significant changes, and the lipid spectra/CRP.

Increasing body mass index in an elderly cohort: Effects on the quantitative MR parameters of the brain

Abstract

Background

Purpose

Study Type

Subjects

Field Strength

Assessment

Statistical Tests

Results

Data Conclusion

Supporting Information

References

Citing Literature

References

Information

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Increasing body mass index in an elderly cohort: Effects on the quantitative MR parameters of the brain

Abstract

Background

Purpose

Study Type

Subjects

Field Strength

Assessment

Statistical Tests

Results

Data Conclusion

Supporting Information

References

Citing Literature

References

Related

Information