Volume 46, Issue 1 pp. 142-149

Original Research

Effects of reduced oxygen availability on the vascular response and oxygen consumption of the activated human visual cortex

Felipe Rodrigues Barreto PhD,

Felipe Rodrigues Barreto PhD

Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil

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Silvia Mangia PhD,

Silvia Mangia PhD

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA

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Carlos Ernesto Garrido Salmon PhD,

Corresponding Author

Carlos Ernesto Garrido Salmon PhD

[email protected]

Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil

Address reprint requests to: C.E.G.S., Av. Bandeirantes, 3900, Ribeirao Preto, SP, Brazil, 14040900. E-mail: [email protected]Search for more papers by this author

Felipe Rodrigues Barreto PhD,

Felipe Rodrigues Barreto PhD

Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil

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Silvia Mangia PhD,

Silvia Mangia PhD

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA

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Carlos Ernesto Garrido Salmon PhD,

Corresponding Author

Carlos Ernesto Garrido Salmon PhD

[email protected]

Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil

Address reprint requests to: C.E.G.S., Av. Bandeirantes, 3900, Ribeirao Preto, SP, Brazil, 14040900. E-mail: [email protected]Search for more papers by this author

First published: 03 November 2016

https://doi.org/10.1002/jmri.25537

Citations: 8

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Abstract

Purpose

To identify the impact of reduced oxygen availability on the evoked vascular response upon visual stimulation in the healthy human brain by magnetic resonance imaging (MRI).

Materials and Methods

Functional MRI techniques based on arterial spin labeling (ASL), blood oxygenation level-dependent (BOLD), and vascular space occupancy (VASO)-dependent contrasts were utilized to quantify the BOLD signal, cerebral blood flow (CBF), and volume (CBV) from nine subjects at 3T (7M/2F, 27.3 ± 3.6 years old) during normoxia and mild hypoxia. Changes in visual stimulus-induced oxygen consumption rates were also estimated with mathematical modeling.

Results

Significant reductions in the extension of activated areas during mild hypoxia were observed in all three imaging contrasts: by 42.7 ± 25.2% for BOLD (n = 9, P = 0.002), 33.1 ± 24.0% for ASL (n = 9, P = 0.01), and 31.9 ± 15.6% for VASO images (n = 7, P = 0.02). Activated areas during mild hypoxia showed responses with similar amplitude for CBF (58.4 ± 18.7% hypoxia vs. 61.7 ± 16.1% normoxia, P = 0.61) and CBV (33.5 ± 17.5% vs. 25.2 ± 13.0%, P = 0.27), but not for BOLD (2.5 ± 0.8% vs. 4.1 ± 0.6%, P = 0.009). The estimated stimulus-induced increases of oxygen consumption were smaller during mild hypoxia as compared to normoxia (3.1 ± 5.0% vs. 15.5 ± 15.1%, P = 0.04).

Conclusion

Our results demonstrate an altered vascular and metabolic response during mild hypoxia upon visual stimulation.

Level of Evidence: 2

Technical Efficacy: Stage 2

J. MAGN. RESON. IMAGING 2017;46:142–149

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Volume46, Issue1

July 2017

Pages 142-149

Effects of reduced oxygen availability on the vascular response and oxygen consumption of the activated human visual cortex

Abstract

Purpose

Materials and Methods

Results

Conclusion

References

Citing Literature

References

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Effects of reduced oxygen availability on the vascular response and oxygen consumption of the activated human visual cortex

Abstract

Purpose

Materials and Methods

Results

Conclusion

References

Citing Literature

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