Volume 33, Issue 2 pp. 306-311

Original Research

MR spectroscopy of normative premature newborns

Duan Xu PhD,

Corresponding Author

Duan Xu PhD

[email protected]

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

1700 4th Street, Byers Hall, Suite 102, UCSF Box 2512, San Francisco, CA 94158Search for more papers by this author

Sonia L. Bonifacio MD,

Sonia L. Bonifacio MD

Department of Neurology and Pediatrics, University of San Francisco, California, USA

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Natalie N. Charlton BS,

Natalie N. Charlton BS

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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Charles P. Vaughan BS,

Charles P. Vaughan BS

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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Ying Lu PhD,

Ying Lu PhD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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Donna M. Ferriero MD,

Donna M. Ferriero MD

Department of Neurology and Pediatrics, University of San Francisco, California, USA

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Daniel B. Vigneron PhD,

Daniel B. Vigneron PhD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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A. James Barkovich MD,

A. James Barkovich MD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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Duan Xu PhD,

Corresponding Author

Duan Xu PhD

[email protected]

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

1700 4th Street, Byers Hall, Suite 102, UCSF Box 2512, San Francisco, CA 94158Search for more papers by this author

Sonia L. Bonifacio MD,

Sonia L. Bonifacio MD

Department of Neurology and Pediatrics, University of San Francisco, California, USA

Search for more papers by this author

Natalie N. Charlton BS,

Natalie N. Charlton BS

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

Search for more papers by this author

Charles P. Vaughan BS,

Charles P. Vaughan BS

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

Search for more papers by this author

Ying Lu PhD,

Ying Lu PhD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

Search for more papers by this author

Donna M. Ferriero MD,

Donna M. Ferriero MD

Department of Neurology and Pediatrics, University of San Francisco, California, USA

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Daniel B. Vigneron PhD,

Daniel B. Vigneron PhD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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A. James Barkovich MD,

A. James Barkovich MD

Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA

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First published: 27 January 2011

https://doi.org/10.1002/jmri.22460

Citations: 40

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Abstract

Purpose

To establish normative metabolite ratios throughout the newborn brain using three-dimensional (3D) MR spectroscopic imaging (MRSI).

Materials and Methods

MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. Fifty-five newborn subjects (28.4 ± 2.6 weeks postconception age at birth, 34.1 ± 3.1 weeks postconception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (neuromotor score = 0, mental development index score > 85) at age 12 months.

Results

The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions.

Conclusion

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Volume33, Issue2

February 2011

Pages 306-311

MR spectroscopy of normative premature newborns

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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MR spectroscopy of normative premature newborns

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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