Technical Note

Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla

Corresponding Author

Richard A.E. Edden PhD

[email protected]

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Department of Radiology, Park 367C, Johns Hopkins University School of Medicine, 600N Wolfe Street, Baltimore, MD 21287Search for more papers by this author

Seth A. Smith PhD,

Seth A. Smith PhD

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Search for more papers by this author

Peter B. Barker DPhil,

Peter B. Barker DPhil

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Search for more papers by this author

Richard A.E. Edden PhD,

Corresponding Author

Richard A.E. Edden PhD

[email protected]

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Department of Radiology, Park 367C, Johns Hopkins University School of Medicine, 600N Wolfe Street, Baltimore, MD 21287Search for more papers by this author

Seth A. Smith PhD,

Seth A. Smith PhD

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Search for more papers by this author

Peter B. Barker DPhil,

Peter B. Barker DPhil

Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and The Kennedy Krieger Institute, Baltimore, Maryland, USA

Search for more papers by this author

First published: 29 September 2010

https://doi.org/10.1002/jmri.22306

Citations: 33

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Abstract

Purpose

To measure longitudinal (T₁) and multi-echo transverse (T₂) relaxation times of healthy breast tissue at 3 Tesla (T).

Materials and Methods

High-resolution relaxation time measurements were made in six healthy female subjects. Inversion recovery images were acquired at 10 inversion times between 100 ms and 4000 ms, and multiple spin echo images were acquired at 16 echo times between 10 ms and 160 ms.

Results

Longitudinal relaxation times T₁ were measured as 423 ± 12 ms for adipose tissue and 1680 ± 180 ms for fibroglandular tissue. Multi-echo transverse relaxation times T₂ were measured as 154 ± 9 ms for adipose tissue and 71 ± 6 ms for fibroglandular tissue. Histograms of the voxel-wise relaxation times and quantitative relaxation time maps are also presented.

Conclusion

T₁ and multi-echo T₂ relaxation times in normal human breast tissue are reported. These values are useful for pulse sequence design and optimization for 3T breast MRI. Compared with the literature, T₁ values are significantly longer at 3T, suggesting that longer repetition time and inversion time values should be used for similar image contrast. J. Magn. Reson. Imaging 2010;32:982–987. © 2010 Wiley-Liss, Inc.

REFERENCES

1 Lehman CD, Smith RA. The role of MRI in breast cancer screening. J Natl Compr Canc Netw 2009; 7: 1109–1115.
10.6004/jnccn.2009.0072
PubMed Web of Science® Google Scholar
2 Schnall MD, Blume J, Bluemke DA, et al. MRI detection of distinct incidental cancer in women with primary breast cancer studied in IBMC 6883. J Surg Oncol 2005; 92: 32–38.
10.1002/jso.20381
PubMed Web of Science® Google Scholar
3 Lehman CD, Gatsonis C, Kuhl CK, et al. MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med 2007; 356: 1295–1303.
10.1056/NEJMoa065447
CAS PubMed Web of Science® Google Scholar
4 Patani N, Mokbel K. The utility of MRI for the screening and staging of breast cancer. Int J Clin Pract 2008; 62: 450–453.
10.1111/j.1742-1241.2007.01677.x
CAS PubMed Web of Science® Google Scholar
5 El Khouli RH, Macura KJ, Barker PB, et al. MRI-guided vacuum-assisted breast biopsy: a phantom and patient evaluation of targeting accuracy. J Magn Reson Imaging 2009; 30: 424–429.
10.1002/jmri.21831
PubMed Web of Science® Google Scholar
6 Rieber A, Brambs HJ, Gabelmann A, Heilmann V, Kreienberg R, Kuhn T. Breast MRI for monitoring response of primary breast cancer to neo-adjuvant chemotherapy. Eur Radiol 2002; 12: 1711–1719.
10.1007/s00330-001-1233-x
CAS PubMed Web of Science® Google Scholar
7 Kuhl CK, Traber F, Schild HH. Whole-body high-field-strength (3.0-T) MR Imaging in clinical practice. I. Technical considerations and clinical applications. Radiology 2008; 246: 675–696.
PubMed Web of Science® Google Scholar
8 Kuhl CK, Jost P, Morakkabati N, Zivanovic O, Schild HH, Gieseke J. Contrast-enhanced MR imaging of the breast at 3.0 and 1.5 T in the same patients: initial experience. Radiology 2006; 239: 666–676.
10.1148/radiol.2392050509
PubMed Web of Science® Google Scholar
9 Kuhl CK. Breast MR imaging at 3T. Magn Reson Imaging Clin N Am 2007; 15: 315–320, vi.
10.1016/j.mric.2007.08.003
PubMed Google Scholar
10 Rakow-Penner R, Daniel B, Yu H, Sawyer-Glover A, Glover GH. Relaxation times of breast tissue at 1.5T and 3T measured using IDEAL. J Magn Reson Imaging 2006; 23: 87–91.
10.1002/jmri.20469
PubMed Web of Science® Google Scholar
11 Constable RT, Anderson AW, Zhong J, Gore JC. Factors influencing contrast in fast spin-echo MR imaging. Magn Reson Imaging 1992; 10: 497–511.
10.1016/0730-725X(92)90001-G
CAS PubMed Web of Science® Google Scholar
12 Griffin CM, Dehmeshki J, Chard DT, et al. T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis. Mult Scler 2002; 8: 211–216.
10.1191/1352458502ms807oa
CAS PubMed Web of Science® Google Scholar
13 Shuman WP, Lambert DT, Patten RM, Baron RL, Tazioli PK. Improved fat suppression in STIR MR imaging: selecting inversion time through spectral display. Radiology 1991; 178: 885–887.
10.1148/radiology.178.3.1994438
CAS PubMed Web of Science® Google Scholar
14 Ogg RJ, Kingsley PB, Taylor JS. WET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy. J Magn Reson B 1994; 104: 1–10.
10.1006/jmrb.1994.1048
CAS PubMed Web of Science® Google Scholar
15 Jacobs MA. Multiparametric magnetic resonance imaging of breast cancer. J Am Coll Radiol 2009; 6: 523–526.
10.1016/j.jacr.2009.04.006
PubMed Google Scholar
16 Henkelman RM, Hardy PA, Bishop JE, Poon CS, Plewes DB. Why fat is bright in RARE and fast spin-echo imaging. J Magn Reson Imaging 1992; 2: 533–540.
10.1002/jmri.1880020511
CAS PubMed Web of Science® Google Scholar
17 el Yousef SJ, O’Connell DM, Duchesneau RH, Smith MJ, Hubay CA, Guyton SP. Benign and malignant breast disease: magnetic resonance and radiofrequency pulse sequences. AJR Am J Roentgenol 1985; 145: 1–8.
10.2214/ajr.145.1.1
CAS PubMed Web of Science® Google Scholar
18 Merchant TE, Thelissen GR, de Graaf PW, Nieuwenhuizen CW, Kievit HC, Den Otter W. Application of a mixed imaging sequence for MR imaging characterization of human breast disease. Acta Radiol 1993; 34: 356–361.
10.1177/028418519303400409
CAS PubMed Web of Science® Google Scholar
19 Partain CL, Kulkarni MV, Price RR, et al. Magnetic resonance imaging of the breast: functional T1 and three-dimensional imaging. Cardiovasc Intervent Radiol 1986; 8: 292–299.
10.1007/BF02552365
CAS PubMed Web of Science® Google Scholar
20 Bottomley PA, Hardy CJ, Argersinger RE, Allen-Moore G. A review of 1H nuclear magnetic resonance relaxation in pathology: are T1 and T2 diagnostic? Med Phys 1987; 14: 1–37.
10.1118/1.596111
CAS PubMed Web of Science® Google Scholar
21 Becker ED, Ferretti JA, Gupta RK, Weiss GH. The choice of optimal parameters for measurement of spin-lattice relaxation times. II. Comparison of saturation recovery, inversion recovery, and fast inversion recovery experiments. J Magn Reson 1980; 37: 381–394.
10.1016/0022-2364(80)90045-1
CAS Web of Science® Google Scholar
22 Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974; 19: 716–723.
10.1109/TAC.1974.1100705
CAS PubMed Web of Science® Google Scholar

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Volume32, Issue4

October 2010

Pages 982-987

Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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