Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI
Corresponding Author
Henrik Nilsson MD
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, Stockholm, Sweden
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, 182 88 Stockholm, SwedenSearch for more papers by this authorAnders Nordell MSc
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorRoberto Vargas RN
Department of Diagnostic Radiology, Karolinska University Hospital Solna, Institution for Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorLena Douglas MSc, PhD
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorEduard Jonas MD, PhD
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, Stockholm, Sweden
Search for more papers by this authorLennart Blomqvist MD, PhD
Department of Diagnostic Radiology, Karolinska University Hospital Solna, Institution for Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden
Department of Diagnostic Radiology, Danderyd Hospital, Stockholm Sweden
Search for more papers by this authorCorresponding Author
Henrik Nilsson MD
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, Stockholm, Sweden
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, 182 88 Stockholm, SwedenSearch for more papers by this authorAnders Nordell MSc
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorRoberto Vargas RN
Department of Diagnostic Radiology, Karolinska University Hospital Solna, Institution for Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorLena Douglas MSc, PhD
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorEduard Jonas MD, PhD
Karolinska Institutet; Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, Stockholm, Sweden
Search for more papers by this authorLennart Blomqvist MD, PhD
Department of Diagnostic Radiology, Karolinska University Hospital Solna, Institution for Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden
Department of Diagnostic Radiology, Danderyd Hospital, Stockholm Sweden
Search for more papers by this authorAbstract
Purpose
To assess the feasibility to use dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) as an imaging-based liver function test, and to compare two methods for deconvolutional analysis (DA) in healthy human subjects.
Materials and Methods
T1-weighted DHCE-MRI with the hepatocyte-specific contrast medium Gd-EOB-DTPA was performed in 20 healthy volunteers. DA was performed using truncated singular value decomposition (TSVD) and Fourier analysis with an appended tail (FA+Tail). Hepatic extraction fraction (HEF) and input relative blood flow (irBF) were calculated for each liver segment. A computer simulation comparing the standard deviation (SD) of TSVD and FA+tail at different levels of signal-to-noise (SNR) ratio was performed. The results obtained were compared using descriptive statistics, the Wilcoxon matched pairs test and the variance ratio test.
Results
Median HEF was 0.201 and 0.205 using TSVD and FA+tail, respectively (P = 0.086). The corresponding results for irBF was 0.240 and 0.239 (P = 0.51). TSVD yielded a smaller SD, although the difference was not significant (P = 0.068 for HEF and P = 0.84 for irBF). The computer simulation showed that TSVD is more stable than FA+tail at most levels of SNR.
Conclusion
DHCE-MRI with Gd-EOB-DTPA enables the calculation of HEF and irBF. We regard these parameters as being markers of hepatic parenchymal function. J. Magn. Reson. Imaging 2009;29:1323–1331. © 2009 Wiley-Liss, Inc.
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