Article
Selective and Efficient Formylation of Indoles (C3) and Pyrroles (C2) Using 2,4,6-Trichloro-1,3,5-Triazine/Dimethylformamide (TCT/DMF) Mixed Reagent
Nasser Iranpoor,
Farhad Panahi,
Soodabeh Erfan,
Fatemeh Roozbin,
Corresponding Author
Nasser Iranpoor
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
E-mail: [email protected]Search for more papers by this authorFarhad Panahi
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorSoodabeh Erfan
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorFatemeh Roozbin
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorNasser Iranpoor,
Farhad Panahi,
Soodabeh Erfan,
Fatemeh Roozbin,
Corresponding Author
Nasser Iranpoor
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
E-mail: [email protected]Search for more papers by this authorFarhad Panahi
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorSoodabeh Erfan
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorFatemeh Roozbin
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454 Iran
Search for more papers by this authorAbstract
This study introduces an efficient method for the selective formylation of indoles and pyrroles at the positions of C(3) and C(2), respectively. The mixture of three equivalents of N,N-dimethylformamide and one equivalent of 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) generates an easy handling formylating agent for the efficient formylation of these classes of compounds to give the corresponding aldehydes under mild reaction conditions. This procedure was highly efficient, and a range of formylated indoles and pyrroles were obtained in good to excellent yields.
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