Synthesis and application of poly(amidoamine) functional biomedical materials in the field of biomedicine over the past decade
Min Zhang
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Search for more papers by this authorCorresponding Author
Dandan Guo
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorXiaoqian Zhou
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Search for more papers by this authorCorresponding Author
Yan Zhu
Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Shaohua Huang
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorMin Zhang
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Search for more papers by this authorCorresponding Author
Dandan Guo
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorXiaoqian Zhou
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Search for more papers by this authorCorresponding Author
Yan Zhu
Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Shaohua Huang
Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China
Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
Correspondence
Dandan Guo and Shaohua Huang, Institute of Drug Discovery and Technology, Ningbo University, Ningbo, China.
Email: [email protected] and [email protected]
Yan Zhu, Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China.
Email: [email protected]
Search for more papers by this authorAbstract
Over the past decade, significant advancements have been achieved in the field of biomedicine, particularly in the treatment of critical illness. However, there remain numerous challenges and barriers persist in drug delivery, medical imaging, diagnosis, and treatment. Poly(amidoamine) (PAMAM) dendrimers have emerged as promising candidates for the development of functional biomedical materials due to their advantageous properties, including ease of preparation, controllable size, abundant cavities, water solubility, modifiability, and biocompatibility. This article presents a comprehensive review of the synthesis, application, and potential toxicity of PAMAM functional biomedical materials, exploring the role, significance, and potential applications of PAMAM dendrimers in detail. The aim is to provide a valuable reference for the future development of biomedical materials and to inspire further discoveries in the field of polyamide functional materials.
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