Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles
Yue Sa
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, People's Republic of China
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorFang Yang
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorSander C. G. Leeuwenburgh
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorJoop G. C. Wolke
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorGuang Ye
Microlab, Delft University of Technology, The Netherlands
Search for more papers by this authorJoost R. de Wijn
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorJohn A. Jansen
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorCorresponding Author
Yining Wang
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, People's Republic of China
Correspondence to: Yining Wang (email: [email protected]) or J.A. Jansen (email: [email protected])Search for more papers by this authorYue Sa
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, People's Republic of China
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorFang Yang
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorSander C. G. Leeuwenburgh
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorJoop G. C. Wolke
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorGuang Ye
Microlab, Delft University of Technology, The Netherlands
Search for more papers by this authorJoost R. de Wijn
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorJohn A. Jansen
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
Search for more papers by this authorCorresponding Author
Yining Wang
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, People's Republic of China
Correspondence to: Yining Wang (email: [email protected]) or J.A. Jansen (email: [email protected])Search for more papers by this authorThis article was published online on 21 June 2014. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 26 July 2014.
Abstract
The main goal of this study was to evaluate the effects of incorporation of calcium phosphate (CaP) particles on the physicochemical properties and mineralization capacity of cements in vitro. Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibiting an interconnected porosity created by mixing with carboxymethylcellulose. The incorporation of CaP particles did not influence the maximum polymerization temperature of the porous PMMA, but reduced the porosity and the average pore size. Small CaP particles formed agglomerations within the PMMA pores, whereas big CaP particles were partially embedded in the PMMA matrix and partially exposed to the pores. Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 548–555, 2015.
REFERENCES
- 1 Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg 1960; 42-B: 28–30.
- 2 Frank KL, Hanssen AD, Patel R. icaA is not a useful diagnostic marker for prosthetic joint infection. J Clin Microbiol 2004; 42: 4846–4849.
- 3 Aamodt A, Nordsletten L, Havelin LI, Indrekvam K, Utvag SE, Hviding K. Documentation of hip prostheses used in Norway: A critical review of the literature from 1996–2000. Acta Orthop Scand 2004; 75: 663–676.
- 4 Berry DJ, Harmsen WS, Cabanela ME, Morrey BF. Twenty-five-year survivorship of two thousand consecutive primary Charnley total hip replacements: Factors affecting survivorship of acetabular and femoral components. J Bone Joint Surg Am 2002; 84-A: 171–177.
- 5 Lye KW, Tideman H, Wolke JC, Merkx MA, Chin FK, Jansen JA. Biocompatibility and bone formation with porous modified PMMA in normal and irradiated mandibular tissue. Clin Oral Implants Res 2011; 40: 86–93.
- 6 Lye KW, Lee S, Tideman H, Merkx MA, Jansen JA. Temperature changes in a cemented mandibular endoprosthesis: In vitro and in vivo studies. Int J Oral Maxillofac Surg 2011; 40: 86–93.
- 7 de Wijn JR. Porous Polymethylmethacrylate Cement: Development and Evaluation of a Potential Implant Material. PhD Thesis. Nijmegen: Catholic University; 1982.
- 8 Fini M, Giavaresi G, Aldini NN, Torricelli P, Botter R, Beruto D, Giardino R. A bone substitute composed of polymethylmethacrylate and alpha-tricalcium phosphate: Results in terms of osteoblast function and bone tissue formation. Biomaterials 2002; 23: 4523–4531.
- 9
Beruto DT,
Mezzasalma SA,
Capurro M,
Botter R,
Cirillo P. Use of alpha-tricalcium phosphate (TCP) as powders and as an aqueous dispersion to modify processing, microstructure, and mechanical properties of polymethylmethacrylate (PMMA) bone cements and to produce bone-substitute compounds. J Biomed Mater Res 2000; 49: 498–505.
10.1002/(SICI)1097-4636(20000315)49:4<498::AID-JBM8>3.0.CO;2-1 CAS PubMed Web of Science® Google Scholar
- 10 Bruens ML, Pieterman H, de Wijn JR, Vaandrager JM. Porous polymethylmethacrylate as bone substitute in the craniofacial area. J Craniofac Surg 2003; 14: 63–68.
- 11 van Mullem PJ, de Wijn JR. Bone and soft connective tissue response to porous acrylic implants. A histokinetic study. J Craniomaxillofac Surg 1988; 16: 99–109.
- 12 Simpson RL, Wiria FE, Amis AA, Chua CK, Leong KF, Hansen UN, Chandrasekaran M, Lee MW. Development of a 95/5 poly(l-lactide-co-glycolide)/hydroxylapatite and β-tricalcium phosphate scaffold as bone replacement material via selective laser sintering. J Biomed Mater Res Part B 2008; 84: 17–25.
- 13 Lopez-Heredia MA, Sa Y, Salmon P, de Wijn JR, Wolke JG, Jansen JA. Bulk properties and bioactivity assessment of porous polymethylmethacrylate cement loaded with calcium phosphates under simulated physiological conditions. Acta Biomater 2012; 8: 3120–3127.
- 14 Wang L, Yoon DM, Spicer PP, Henslee AM, Scott DW, Wong ME, Kasper FK, Mikos AG. Characterization of porous polymethylmethacrylate space maintainers for craniofacial reconstruction. J Biomed Mater Res Part B 2013; 101: 813–825.
- 15 Spicer PP, Kretlow JD, Henslee AM, Shi M, Young S, Demian N, Jansen JA, Wong ME, Mikos AG, Kasper FK. In situ formation of porous space maintainers in a composite tissue defect. J Biomed Mater Res Part A 2012; 100: 827–833.
- 16 van Mullem PJ, de Wijn JR, Vaandrager JM. Porous acrylic cement: evaluation of a novel implant material. Ann Plastic Surg 1988; 21: 576–582.
- 17 Shi M, Kretlow JD, Nguyen A, Young S, Scott Baggett L, Wong ME, Kasper FK, Mikos AG. Antibiotic-releasing porous polymethylmethacrylate constructs for osseous space maintenance and infection control. Biomaterials 2010; 31: 4146–4156.
- 18 Bianchi M, Urquia Edreira ER, Wolke JG, Birgani ZT, Habibovic P, Jansen JA, Tampieri A, Marcacci M, Leeuwenburgh SC, van den Beucken JJ. Substrate geometry directs the in vitro mineralization of calcium phosphate ceramics. Acta Biomater 2014; 10: 661–669.
- 19 Dorozhkin SV. Bioceramics of calcium orthophosphates. Biomaterials 2010; 31: 1465–1485.
- 20 Ruhé P, Wolke J, Spauwen P, Jansen J. Calcium phosphate ceramics for bone tissue engineering. Biomedical engineering handbook, section tissue engineering, 3rd ed. Connecticut: CRC Press; 2005.
- 21 Washburn EW. The dynamics of capillary flow. Phys Rev 1921; 17: 273–283.
- 22 Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res 1990; 24: 721–734.
- 23 Euler E, Bauer J, Jonck L, Kreusser T. Thermotoxicity of palacos cement. Clinical observation. Der Unfallchirurg 1989; 92: 606–610.
- 24 Abdel-Kader KF, Allcock S, Walker DI, Chaudhry SB. Boneloc bone-cement: Experience in hip arthroplasty during a 3-year period. J Arthroplasty 2001; 16: 811–819.
- 25 Oh SH, Choi SY, Choi SH, Lee YK, Kim KN. The influence of lithium fluoride on in vitro biocompatibility and bioactivity of calcium aluminate-pMMA composite cement. J Mater Sci 2004; 15: 25–33.
- 26 Nge TT, Sugiyama J. Surface functional group dependent apatite formation on bacterial cellulose microfibrils network in a simulated body fluid. J Biomed Mater Res Part A 2007; 81: 124–134.
- 27 Koh M-Y, Morita Y, Miyazaki T, Ohtsuki C. In vitro apatite-forming ability of hydrogels derived from sodium carboxymethylcellulose. In: IOP Conference Series: Materials Science and Engineering. Bristol, UK, 2011; 18: 192004.
- 28 Link DP, van den Dolder J, Wolke JG, Jansen JA. The cytocompatibility and early osteogenic characteristics of an injectable calcium phosphate cement. Tissue Eng 2007; 13: 493–500.
- 29 Link DP, van den Dolder J, van den Beucken JJ, Cuijpers VM, Wolke JG, Mikos AG, Jansen JA. Evaluation of the biocompatibility of calcium phosphate cement/PLGA microparticle composites. J Biomed Mater Res Part A 2008; 87: 760–769.
- 30 Lu JX, Flautre B, Anselme K, Hardouin P, Gallur A, Descamps M, Thierry B. Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci 1999; 10: 111–120.
- 31 Baroud G, Nemes J, Heini P, Steffen T. Load shift of the intervertebral disc after a vertebroplasty: A finite-element study. Eur Spine J 2003; 12: 421–426.
- 32 Boger A, Bohner M, Heini P, Verrier S, Schneider E. Properties of an injectable low modulus PMMA bone cement for osteoporotic bone. J Biomed Mater Res Part B 2008; 86: 474–482.
- 33 Baroud G, Bohner M. Biomechanical impact of vertebroplasty. Postoperative biomechanics of vertebroplasty. Joint Bone Spine 2006; 73: 144–150.
