Fabrication of a heparin–PVA complex hydrogel for application as a vascular access
Jun Negishi
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Search for more papers by this authorCorresponding Author
Kwangwoo Nam
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Correspondence to: K. Nam (e-mail: [email protected])Search for more papers by this authorTsuyoshi Kimura
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Search for more papers by this authorYoshihide Hashimoto
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Search for more papers by this authorSeiichi Funamoto
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University, S1W16, Sapporo City, Hokkaido, 060–8543 Japan
Search for more papers by this authorTetsuya Higami
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University, S1W16, Sapporo City, Hokkaido, 060–8543 Japan
Search for more papers by this authorToshiya Fujisato
Department of Biomedical Engineering, Osaka Institute of Technology, Asahi-ku, Osaka, 535–8585 Japan
Search for more papers by this authorAkio Kishida
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Search for more papers by this authorJun Negishi
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Search for more papers by this authorCorresponding Author
Kwangwoo Nam
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Correspondence to: K. Nam (e-mail: [email protected])Search for more papers by this authorTsuyoshi Kimura
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Search for more papers by this authorYoshihide Hashimoto
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Search for more papers by this authorSeiichi Funamoto
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University, S1W16, Sapporo City, Hokkaido, 060–8543 Japan
Search for more papers by this authorTetsuya Higami
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University, S1W16, Sapporo City, Hokkaido, 060–8543 Japan
Search for more papers by this authorToshiya Fujisato
Department of Biomedical Engineering, Osaka Institute of Technology, Asahi-ku, Osaka, 535–8585 Japan
Search for more papers by this authorAkio Kishida
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062 Japan
Japan Science and Technology Agency, CREST, Chiyoda-ku, Tokyo, 102-0075 Japan
Search for more papers by this authorAbstract
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin–PVA hydrogel conduit and evaluate its potential for vascular access. Heparin–PVA complex hydrogel showed suppressed heparin release and prevented clot formation, depending on the molecular weight of the PVA. Strength of the hydrogel conduit was increased by embedding a Dacron® mesh between two PVA layers. The tubular heparin–PVA complex hydrogel displayed a burst pressure of 750 mmHg. The tubular heparin–PVA complex hydrogel did not show any occlusion or burst for 2 weeks after implantation, implying that this heparin–PVA complex hydrogel shows high potential for use as a vascular access. This is the first report on the preparation of a multilayered PVA hydrogel with heparin embedded on one side only. The proposed approach could be expanded to the fabrication of various biomaterials for specific purposes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1426–1433, 2014.
Supporting Information
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