Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites
Corresponding Author
Lídia Ágata de Sena
Divisão de Metrologia de Materiais, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Correspondence to: L. A. de Sena; e-mail: [email protected]Search for more papers by this authorMarcelo Sanmartin de Almeida
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Search for more papers by this authorGustavo V. de Oliveira Fernandes
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Search for more papers by this authorRosa M. Guerra Bretaña
Centro de Biomateriales, Universidad de La Habana, Ave. Universidad e/ Ronda y G, CP 10400, La Habana, Cuba
Search for more papers by this authorIgor Iuco Castro-Silva
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Faculdade de Ciencias do Tocantins (FACIT), Araguaina, Tocantins, Brazil
Search for more papers by this authorJosé Mauro Granjeiro
Diretoria de Metrologia Aplicada às Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Search for more papers by this authorCarlos Alberto Achete
Divisão de Metrologia de Materiais, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Search for more papers by this authorCorresponding Author
Lídia Ágata de Sena
Divisão de Metrologia de Materiais, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Correspondence to: L. A. de Sena; e-mail: [email protected]Search for more papers by this authorMarcelo Sanmartin de Almeida
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Search for more papers by this authorGustavo V. de Oliveira Fernandes
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Search for more papers by this authorRosa M. Guerra Bretaña
Centro de Biomateriales, Universidad de La Habana, Ave. Universidad e/ Ronda y G, CP 10400, La Habana, Cuba
Search for more papers by this authorIgor Iuco Castro-Silva
Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, RJ, CEP 24.020-150, Brazil
Faculdade de Ciencias do Tocantins (FACIT), Araguaina, Tocantins, Brazil
Search for more papers by this authorJosé Mauro Granjeiro
Diretoria de Metrologia Aplicada às Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Search for more papers by this authorCarlos Alberto Achete
Divisão de Metrologia de Materiais, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil
Search for more papers by this authorAbstract
Wollastonite-poly(n-butyl-2-cyanoacrylate) composite (W-BCA) has been proposed to immobilize anatomically bone fragments in order to achieve an optimal healing process. The present study evaluated the in vitro and in vivo behavior of three types of fillers: powdered natural wollastonite (Wn), synthetic pseudowollastonite powder (Ws), and synthetic pseudowollastonite powder coated with 5% acetyl tributyl citrate (Wst). The Wst-BCA composite underwent a higher degradability in the real-time degradation test and a superior cytotoxic effect; whereas the Wn-BCA composite showed a higher degradability in the accelerated test with no cytotoxicity. The formation of an extracellular collagenous matrix deposit on its surface and the most favorable new bone formation on Wn-BCA indicate its potential for bone adhesive use in unstable orthopedic traumas. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1121–1129, 2014.
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