Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method
Takeshi Mizuno
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Department of Veterinary Medicine, Veterinary Cardiovascular Medicine and Surgery Unit, Laboratory of Veterinary Internal Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
Search for more papers by this authorYoshiaki Takewa
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorHirohito Sumikura
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorKentaro Ohnuma
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorTakeshi Moriwaki
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorMasashi Yamanami
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorTomonori Oie
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorEisuke Tatsumi
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorMasami Uechi
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Department of Veterinary Medicine, Veterinary Cardiovascular Medicine and Surgery Unit, Laboratory of Veterinary Internal Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
Search for more papers by this authorCorresponding Author
Yasuhide Nakayama
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Correspondence to: Y. Nakayama (e-mail: [email protected])Search for more papers by this authorTakeshi Mizuno
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Department of Veterinary Medicine, Veterinary Cardiovascular Medicine and Surgery Unit, Laboratory of Veterinary Internal Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
Search for more papers by this authorYoshiaki Takewa
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorHirohito Sumikura
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorKentaro Ohnuma
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorTakeshi Moriwaki
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorMasashi Yamanami
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorTomonori Oie
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorEisuke Tatsumi
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Search for more papers by this authorMasami Uechi
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Department of Veterinary Medicine, Veterinary Cardiovascular Medicine and Surgery Unit, Laboratory of Veterinary Internal Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
Search for more papers by this authorCorresponding Author
Yasuhide Nakayama
Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Correspondence to: Y. Nakayama (e-mail: [email protected])Search for more papers by this authorAbstract
We designed a novel method for constructing an autologous heart valve with a stent, called a stent-biovalve. In constructing completely autologous heart valves, named biovalves, which used in-body tissue architecture technology, tissues for leaflets were formed via ingrowths into narrow apertures in the preparation molds, frequently leading to delayed or incomplete biovalve preparation. In this technique, self-expandable nitinol stents after everting were mounted on an acrylic column-shaped part and partially covered with an acrylic cylinder-shaped part with three slits. This assembled mold was placed into subcutaneous abdominal pouches in beagles or goats for 4 weeks. Upon removing the acrylic parts after harvesting and trimming of capsulated tissues, a tubular hollow structure with three pocket-flaps of membranous tissue rigidly fixed to the stent's outer surface was obtained. Then, the stent was turned inside out to the original form, thus moving the pocket-flaps from outside to the inside. Stent-biovalves with a sufficient coaptation area were thus obtained with little tissue damage in all cases. The valve opened smoothly, and high aperture ratio was noted. This novel technique was thus highly effective in constructing a robust, completely autologous stent-biovalve with adequate valve function. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1038–1045, 2014.
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