Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium
Corresponding Author
Helen D. Bailey
International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, France
Correspondence to: Helen Bailey, Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372 Cedex 08, France, Tel.: +33-4-72-73-8310, Fax: +33-4-72-73-8320, E-mail: [email protected]Search for more papers by this authorLin Fritschi
Curtin University, School of Public Health, Perth, Australia
Search for more papers by this authorClaire Infante-Rivard
Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Quebec, Canada
Search for more papers by this authorDeborah C. Glass
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Search for more papers by this authorLucia Miligi
ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy
Search for more papers by this authorJohn D. Dockerty
Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Search for more papers by this authorTracy Lightfoot
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorJacqueline Clavel
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorEve Roman
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorLogan G. Spector
Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, MN
Search for more papers by this authorPeter Kaatsch
German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Mainz, Germany
Search for more papers by this authorCatherine Metayer
University of California, Berkeley, School of Public Health, Berkeley, CA
Search for more papers by this authorCorrado Magnani
Dipartimento di Medicina Traslazionale—Università del Piemonte Orientale, AOU Maggiore della Carità e CPO—Piemonte, Novara, Italy
Search for more papers by this authorElizabeth Milne
Telethon Kids Institute, the University of Western Australia, Perth, Australia
Search for more papers by this authorSophia Polychronopoulou
Department of Pediatric Hematology–Oncology, Athens University Medical School, “Aghia Sophia” General Children's Hospital, Athens, Greece
Search for more papers by this authorJill Simpson
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorJérémie Rudant
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorVasiliki Sidi
Department of Pediatric Hematology–Oncology, Ippokrateion Hospital, Salonica, Greece
Search for more papers by this authorRoberto Rondelli
Department of Paediatric Haematology–Oncology, Lalla Seràgnoli, Policlinico Sant'Orsola Malpighi, Bologna, Italy
Search for more papers by this authorLaurent Orsi
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorAlice Y. Kang
University of California, Berkeley, School of Public Health, Berkeley, CA
Search for more papers by this authorEleni Petridou
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Search for more papers by this authorJoachim Schüz
International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, France
Search for more papers by this authorCorresponding Author
Helen D. Bailey
International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, France
Correspondence to: Helen Bailey, Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372 Cedex 08, France, Tel.: +33-4-72-73-8310, Fax: +33-4-72-73-8320, E-mail: [email protected]Search for more papers by this authorLin Fritschi
Curtin University, School of Public Health, Perth, Australia
Search for more papers by this authorClaire Infante-Rivard
Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Quebec, Canada
Search for more papers by this authorDeborah C. Glass
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Search for more papers by this authorLucia Miligi
ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy
Search for more papers by this authorJohn D. Dockerty
Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Search for more papers by this authorTracy Lightfoot
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorJacqueline Clavel
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorEve Roman
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorLogan G. Spector
Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, MN
Search for more papers by this authorPeter Kaatsch
German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Mainz, Germany
Search for more papers by this authorCatherine Metayer
University of California, Berkeley, School of Public Health, Berkeley, CA
Search for more papers by this authorCorrado Magnani
Dipartimento di Medicina Traslazionale—Università del Piemonte Orientale, AOU Maggiore della Carità e CPO—Piemonte, Novara, Italy
Search for more papers by this authorElizabeth Milne
Telethon Kids Institute, the University of Western Australia, Perth, Australia
Search for more papers by this authorSophia Polychronopoulou
Department of Pediatric Hematology–Oncology, Athens University Medical School, “Aghia Sophia” General Children's Hospital, Athens, Greece
Search for more papers by this authorJill Simpson
Department of Health Sciences, University of York, York, United Kingdom
Search for more papers by this authorJérémie Rudant
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorVasiliki Sidi
Department of Pediatric Hematology–Oncology, Ippokrateion Hospital, Salonica, Greece
Search for more papers by this authorRoberto Rondelli
Department of Paediatric Haematology–Oncology, Lalla Seràgnoli, Policlinico Sant'Orsola Malpighi, Bologna, Italy
Search for more papers by this authorLaurent Orsi
Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France
Search for more papers by this authorAlice Y. Kang
University of California, Berkeley, School of Public Health, Berkeley, CA
Search for more papers by this authorEleni Petridou
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Search for more papers by this authorJoachim Schüz
International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, France
Search for more papers by this authorAbstract
Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.
Abstract
What's new?
When parents are exposed to pesticides during pregnancy or conception, does this increase the risk of leukemia in their child? The answer is yes. Using pooled individual level occupational pesticide exposure data from 13 case-control studies the authors found an increased risk of acute myeloid leukemia with maternal exposure during pregnancy and a slightly increased risk of acute lymphoblastic leukemia with paternal exposure around conception. The next step is to get more detailed information on pesticide types and protective measures during application before conclusive recommendations for pesticide use in the workforce can be made.
Supporting Information
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| ijc28854-sup-0004-supptable1.doc124 KB | Supporting Information Table 1. |
| ijc28854-sup-0005-supptable2.doc1.2 MB | Supporting Information Table 2. |
| ijc28854-sup-0006-supptable3.doc76.5 KB | Supporting Information Table 3. |
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