Short Report

Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica

Corresponding Author

Sophia S. Wang

[email protected]

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

Fax: +301-402-0817.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7070, Rockville, MD 20852, USASearch for more papers by this author

J. Daniel Carreon,

J. Daniel Carreon

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

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Barrie Hanchard,

Barrie Hanchard

Department of Pathology, University of the West Indies, Kingston, Jamaica

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Stephen Chanock,

Stephen Chanock

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

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Michie Hisada,

Michie Hisada

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

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Sophia S. Wang,

Corresponding Author

Sophia S. Wang

[email protected]

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

Fax: +301-402-0817.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7070, Rockville, MD 20852, USASearch for more papers by this author

J. Daniel Carreon,

J. Daniel Carreon

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

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Barrie Hanchard,

Barrie Hanchard

Department of Pathology, University of the West Indies, Kingston, Jamaica

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Stephen Chanock,

Stephen Chanock

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

Search for more papers by this author

Michie Hisada,

Michie Hisada

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD

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First published: 14 July 2009

https://doi.org/10.1002/ijc.24489

Citations: 12

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Abstract

We evaluated whether risk of non-Hodgkin lymphoma (NHL), particularly adult T-cell leukemia/lymphoma (ATL) related to human T-lymphotropic virus (HTLV) infection was associated with 63 single nucleotide polymorphisms (SNPs) from 38 candidate genes. The 395 NHL cases registered in Jamaica were matched by age, sex, calendar-year and HTLV serostatus to 309 controls from the same population. Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (OR_AG/AA = 0.62,95% CI = 0.44–0.87, p = 0.006), as was vascular cell adhesion molecule-1, VCAM1 Ex9+149G>A SNP (rs1041163) (OR_CT = 0.77, 95% CI = 0.54–1.10, OR_CC=0.35, 95% CI = 0.16–0.76, p-trend = 0.007). Both results were stronger in analyses restricted to ATL cases and HTLV-positive controls, suggesting a role for these genes in ATL etiology (IL13 OR_AG/AA = 0.54, 95% CI = 0.36–0.84, p = 0.005; VCAM1 OR_CT = 0.65, 95% CI = 0.42–1.01, OR_CC = 0.20, 95% CI = 0.08–0.54, p-trend = 0.001). Confirmation of these results in Caribbean and other populations is needed. © 2009 UICC

Supporting Information

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Citing Literature

Volume125, Issue6

15 September 2009

Pages 1479-1482

Filename	Description
IJC_24489_sm_supptable1.pdf36.4 KB	Supporting Table 1
IJC_24489_sm_supptable2.pdf146 KB	Supporting Table 2
IJC_24489_sm_supptable3.pdf139.8 KB	Supporting Table 3

Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica

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Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica

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