Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin
Corresponding Author
Mateusz Kwitniewski
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, 38 Do Studzienki Str., 80-227 Gdansk, PolandSearch for more papers by this authorDawid Jankowski
Department of Acousto-Optics and Laser Physics, Institute of Experimental Physics, University of Gdansk, Gdansk, Poland
Search for more papers by this authorKazimierz Jaskiewicz
Department of Pathology, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorHalina Dziadziuszko
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Search for more papers by this authorJohan Moan
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Institute of Physics, University of Oslo, Blindern, Oslo, Norway
Search for more papers by this authorLi-Wei Ma
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Search for more papers by this authorRafal Peksa
Department of Pathology, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorDanuta Kunikowska
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorAlfreda Graczyk
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorMiroslaw Kwasny
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorMiron Kaliszewski
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorCorresponding Author
Mateusz Kwitniewski
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, 38 Do Studzienki Str., 80-227 Gdansk, PolandSearch for more papers by this authorDawid Jankowski
Department of Acousto-Optics and Laser Physics, Institute of Experimental Physics, University of Gdansk, Gdansk, Poland
Search for more papers by this authorKazimierz Jaskiewicz
Department of Pathology, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorHalina Dziadziuszko
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Search for more papers by this authorJohan Moan
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Institute of Physics, University of Oslo, Blindern, Oslo, Norway
Search for more papers by this authorLi-Wei Ma
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
Search for more papers by this authorRafal Peksa
Department of Pathology, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorDanuta Kunikowska
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland
Search for more papers by this authorAlfreda Graczyk
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorMiroslaw Kwasny
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorMiron Kaliszewski
Institute of Optoelectronics, Military University of Technology, Warsaw, Poland
Search for more papers by this authorAbstract
Photodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)2, PP(Ser)2Arg2, PP(Ala)2Arg2, all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). Of these drugs, ALA and PP(Arg)2 were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed. © 2009 UICC
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