HOX D13 expression across 79 tumor tissue types
Monica Cantile
Department of Clinical & Experimental Medicine, Federico II University Medical School, Naples, Italy
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorRenato Franco
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorAdrienne Tschan
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorDaniel Baumhoer
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorInti Zlobec
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorGiulia Schiavo
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorIris Forte
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorMichel Bihl
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorGiuseppina Liguori
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorGerardo Botti
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorLuigi Tornillo
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorEva Karamitopoulou-Diamantis
Second Department of Pathology, University of Athens, Athens, Greece
Search for more papers by this authorLuigi Terracciano
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Health Science Department, University of Molise, Italy
Search for more papers by this authorCorresponding Author
Clemente Cillo
Department of Clinical & Experimental Medicine, Federico II University Medical School, Naples, Italy
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Fax: +0039-081-5454790.
Department of Clinical & Experimental Medicine, Federico II University Medical School, Via S. Pansini 5, 80131 Naples, ItalySearch for more papers by this authorMonica Cantile
Department of Clinical & Experimental Medicine, Federico II University Medical School, Naples, Italy
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorRenato Franco
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorAdrienne Tschan
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Monica Cantile, Renato Franco and Adrienne Tschan contributed equally to this work.
Search for more papers by this authorDaniel Baumhoer
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorInti Zlobec
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorGiulia Schiavo
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorIris Forte
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorMichel Bihl
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorGiuseppina Liguori
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorGerardo Botti
Surgical Pathology Department, National Cancer Institute “G.Pascale,” Naples, Italy
Search for more papers by this authorLuigi Tornillo
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Search for more papers by this authorEva Karamitopoulou-Diamantis
Second Department of Pathology, University of Athens, Athens, Greece
Search for more papers by this authorLuigi Terracciano
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Health Science Department, University of Molise, Italy
Search for more papers by this authorCorresponding Author
Clemente Cillo
Department of Clinical & Experimental Medicine, Federico II University Medical School, Naples, Italy
Molecular Pathology Department, Institute of Pathology, University of Basel, Basel, Switzerland
Fax: +0039-081-5454790.
Department of Clinical & Experimental Medicine, Federico II University Medical School, Via S. Pansini 5, 80131 Naples, ItalySearch for more papers by this authorAbstract
HOX genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. Locus D HOX genes play an important role in limb generation and mesenchymal condensation. Dysregulated HOXD13 expression has been detected in breast cancer, melanoma, cervical cancer and astrocytomas. We have investigated the epidemiology of HOXD13 expression in human tissues and its potential deregulation in the carcinogenesis of specific tumors. HOXD13 homeoprotein expression has been detected using microarray technology comprising more than 4,000 normal and neoplastic tissue samples including 79 different tumor categories. Validation of HOXD13 expression has been performed, at mRNA level, for selected tumor types. Significant differences are detectable between specific normal tissues and corresponding tumor types with the majority of cancers showing an increase in HOXD13 expression (16.1% normal vs. 57.7% cancers). In contrast, pancreas and stomach tumor subtypes display the opposite trend. Interestingly, detection of the HOXD13 homeoprotein in pancreas-tissue microarrays shows that its negative expression has a significant and adverse effect on the prognosis of patients with pancreatic cancer independent of the T or N stage at the time of diagnosis. Our study provides, for the first time, an overview of a HOX protein expression in a large series of normal and neoplastic tissue types, identifies pancreatic cancer as one of the most affected by the HOXD13 hoemoprotein and underlines the way homeoproteins can be associated to human cancerogenesis. © 2009 UICC
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