A prospective evaluation of health-related quality of life after skull base re-irradiation
Houda Bahig MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorSweet P. Ng MBBS, FRANZCR
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCourtney Pollard III MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorTheresa P. Nguyen BS
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorGary B. Gunn MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorDavid I. Rosenthal MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorClifton D. Fuller MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorSteven J. Frank MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorAdam S. Garden MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorJay P. Reddy MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorWilliam H. Morrison MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorRenata Ferrarotto MD
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorEhab Y. Hanna MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorFranco DeMonte MD
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorShirley Y. Su MBBS, FRACS
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCorresponding Author
Jack Phan MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Correspondence
Jack Phan, MD, PhD, 1515 Holcombe Blvd. Unit 0097, University of Texas MD Anderson Cancer Center, Houston, TX, 77030.
Email: [email protected]
Search for more papers by this authorHouda Bahig MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorSweet P. Ng MBBS, FRANZCR
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCourtney Pollard III MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorTheresa P. Nguyen BS
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorGary B. Gunn MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorDavid I. Rosenthal MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorClifton D. Fuller MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorSteven J. Frank MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorAdam S. Garden MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorJay P. Reddy MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorWilliam H. Morrison MD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorRenata Ferrarotto MD
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorEhab Y. Hanna MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorFranco DeMonte MD
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorShirley Y. Su MBBS, FRACS
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCorresponding Author
Jack Phan MD, PhD
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Correspondence
Jack Phan, MD, PhD, 1515 Holcombe Blvd. Unit 0097, University of Texas MD Anderson Cancer Center, Houston, TX, 77030.
Email: [email protected]
Search for more papers by this authorAbstract
Purpose
To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT).
Methods
Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires.
Results
Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous.
Conclusion
Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.
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