Volume 42, Issue 3 pp. 513-521

ORIGINAL ARTICLE

Mapping the University of Washington Quality of life questionnaire onto EQ-5D and HUI-3 indices in patients with head and neck cancer

Robert F. Stephens MSc,

Robert F. Stephens MSc

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Christopher W. Noel MD,

Christopher W. Noel MD

orcid.org/0000-0002-6625-0809

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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Jie (Susie) Su MSc,

Jie (Susie) Su MSc

Department of Biostatistics, University Health Network, Toronto, Ontario, Canada

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Wei Xu PhD,

Wei Xu PhD

Department of Biostatistics, University Health Network, Toronto, Ontario, Canada

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Murray Krahn MD, MSc,

Murray Krahn MD, MSc

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Eric Monteiro MD, MSc, FRCSC,

Eric Monteiro MD, MSc, FRCSC

Department of Otolaryngology-Head and Neck Surgery, Sinai Health System, University of Toronto, Toronto, Ontario, Canada

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David P. Goldstein MD, MSc, FRCSC,

David P. Goldstein MD, MSc, FRCSC

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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Meredith Giuliani MBBS, MEd, FRCSC,

Meredith Giuliani MBBS, MEd, FRCSC

Department of Radiation Oncology, Princess Margaret Cancer Centre—University Health Network, University of Toronto, Toronto, Ontario, Canada

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Aaron R. Hansen MBBS, FRACP,

Aaron R. Hansen MBBS, FRACP

Department of Medical Oncology, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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John R. de Almeida MD, MSc, FRCSC,

Corresponding Author

John R. de Almeida MD, MSc, FRCSC

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

Correspondence

John R. de Almeida, Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, 610 University Avenue, 3-955, Toronto, Ontario M5G 2M9, Canada.

Email: [email protected]

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Robert F. Stephens MSc,

Robert F. Stephens MSc

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Christopher W. Noel MD,

Christopher W. Noel MD

orcid.org/0000-0002-6625-0809

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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Jie (Susie) Su MSc,

Jie (Susie) Su MSc

Department of Biostatistics, University Health Network, Toronto, Ontario, Canada

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Wei Xu PhD,

Wei Xu PhD

Department of Biostatistics, University Health Network, Toronto, Ontario, Canada

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Murray Krahn MD, MSc,

Murray Krahn MD, MSc

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Eric Monteiro MD, MSc, FRCSC,

Eric Monteiro MD, MSc, FRCSC

Department of Otolaryngology-Head and Neck Surgery, Sinai Health System, University of Toronto, Toronto, Ontario, Canada

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David P. Goldstein MD, MSc, FRCSC,

David P. Goldstein MD, MSc, FRCSC

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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Meredith Giuliani MBBS, MEd, FRCSC,

Meredith Giuliani MBBS, MEd, FRCSC

Department of Radiation Oncology, Princess Margaret Cancer Centre—University Health Network, University of Toronto, Toronto, Ontario, Canada

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Aaron R. Hansen MBBS, FRACP,

Aaron R. Hansen MBBS, FRACP

Department of Medical Oncology, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

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John R. de Almeida MD, MSc, FRCSC,

Corresponding Author

John R. de Almeida MD, MSc, FRCSC

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Princess Margaret Cancer Centre–University Health Network, University of Toronto, Toronto, Ontario, Canada

Correspondence

Email: [email protected]

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First published: 24 November 2019

https://doi.org/10.1002/hed.26031

Citations: 10

Robert F. Stephens and Christopher W. Noel contributed equally to the study.

Section Editor: Allen Sherman

This work was accepted for podium presentation at the 2019 American Head and Neck Society Annual Meeting.

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Abstract

Background

There is no mechanism to predict health utility (HU) values from the University of Washington Quality of Life Questionnaire (UWQoL) scores. We sought to develop a mapping algorithm capable of using UWQoL data to approximate HU scores.

Methods

Outpatients with head and neck cancer completed the UWQoL, EQ-5D, and the Health Utilities Index-Mark 3 (HUI-3). Results of the UWQoL were mapped onto both EQ-5D and HUI-3 scores using ordinary least-squares regression models. Two-part models were explored. The predictive power of the model was assessed using 10-fold cross-validation.

Results

A total of 209 patients were recruited. The reduced model converting UWQoL data into EQ-5D scores performed best (adjusted R² = 0.628, root mean square error = 0.076). Both models demonstrated construct validity by discriminating between clinical indices of disease severity.

Conclusions

The abovementioned algorithms enable researchers to perform health economic evaluations with existing UWQoL data in cases where prospectively collected HU values are not available.

CONFLICT OF INTEREST

The authors declare no potential conflict of interest.

Supporting Information

REFERENCES

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Citing Literature

Volume42, Issue3

March 2020

Pages 513-521

Filename	Description
hed26031-sup-0001-AppendixS1.docxWord 2007 document , 21.9 KB	Appendix S1: Supporting information
hed26031-sup-0002-AppendixS2.docxWord 2007 document , 473 KB	Appendix S2: Supporting information
hed26031-sup-0003-AppendixS3.docxWord 2007 document , 15.2 KB	Appendix S3: Supporting information

Mapping the University of Washington Quality of life questionnaire onto EQ-5D and HUI-3 indices in patients with head and neck cancer

Abstract

Background

Methods

Results

Conclusions

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Information

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Mapping the University of Washington Quality of life questionnaire onto EQ-5D and HUI-3 indices in patients with head and neck cancer

Abstract

Background

Methods

Results

Conclusions

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Related

Information