Volume 38, Issue 4 pp. 606-612

Original Article

Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals

Francesco Bussu MD,

Francesco Bussu MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Federica Mura MD,

Federica Mura MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Francesco Miccichè MD,

Francesco Miccichè MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Giulia Bertino MD,

Giulia Bertino MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Antonio Occhini MD,

Antonio Occhini MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Giovanni Almadori MD,

Giovanni Almadori MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Jacopo Galli MD,

Jacopo Galli MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Manlio Pandolfini MD,

Manlio Pandolfini MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Roberto Gallus MD,

Corresponding Author

Roberto Gallus MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

Corresponding author: R. Gallus, Institute of Otorhinolaryngology, Università Cattolica-Policlinico Agostino Gemelli, 00168 Rome, Italy. E-mail: [email protected]Search for more papers by this author

Rosa Autorino MD,

Rosa Autorino MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Maria Lavinia Guidi MD,

Maria Lavinia Guidi MD

Institute of Anesthesiology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Nicola Dinapoli MD,

Nicola Dinapoli MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Vincenzo Valentini MD,

Vincenzo Valentini MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Gaetano Paludetti MD,

Gaetano Paludetti MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Marco Benazzo MD,

Marco Benazzo MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Francesco Bussu MD,

Francesco Bussu MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Federica Mura MD,

Federica Mura MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Francesco Miccichè MD,

Francesco Miccichè MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Giulia Bertino MD,

Giulia Bertino MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Antonio Occhini MD,

Antonio Occhini MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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Giovanni Almadori MD,

Giovanni Almadori MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Jacopo Galli MD,

Jacopo Galli MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Manlio Pandolfini MD,

Manlio Pandolfini MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Roberto Gallus MD,

Corresponding Author

Roberto Gallus MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

Rosa Autorino MD,

Rosa Autorino MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Maria Lavinia Guidi MD,

Maria Lavinia Guidi MD

Institute of Anesthesiology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Nicola Dinapoli MD,

Nicola Dinapoli MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Vincenzo Valentini MD,

Vincenzo Valentini MD

Institute of Radiotherapy, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Gaetano Paludetti MD,

Gaetano Paludetti MD

Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

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Marco Benazzo MD,

Marco Benazzo MD

Institute of Otorhinolaryngology, Policlinico S. Matteo, Università di Pavia, Italy

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First published: 09 December 2014

https://doi.org/10.1002/hed.23938

Citations: 9

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Abstract

Background

The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities.

Methods

The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed. The correlations of oncologic endpoints with tumor parameters and primary treatment were evaluated.

Results

The overall survival (OS) rate was 76% and the disease-specific survival (DSS) rate was 80% at 3 years in the entire group. Sex and T and N classifications significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and radiotherapy (RT), and the temporal sequence of the 2 modalities did not affect prognosis.

Conclusion

The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in univariate and multivariate analyses for any stage considered. © 2015 Wiley Periodicals, Inc. Head Neck 38: 606–612, 2016

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Volume38, Issue4

April 2016

Pages 606-612

Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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