Volume 37, Issue 1 pp. 117-124

Original Article

Proton therapy for head and neck adenoid cystic carcinoma: Initial clinical outcomes

Okechukwu R. Linton MD,

Okechukwu R. Linton MD

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana

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Michael G. Moore MD,

Michael G. Moore MD

Department of Otolaryngology/Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana

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Joseph S. Brigance MD,

Joseph S. Brigance MD

Department of Otolaryngology/Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana

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Don-John Summerlin DMD, MS,

Don-John Summerlin DMD, MS

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana

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Mark W. McDonald MD,

Corresponding Author

Mark W. McDonald MD

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana

Indiana University Health Proton Therapy Center, Bloomington, Indiana

Corresponding author: M. W. McDonald, Indiana University Health Proton Therapy Center, 2425 North Milo B. Sampson Lane, Bloomington, IN 47408-1398. E-mail: [email protected]Search for more papers by this author

Okechukwu R. Linton MD,

Okechukwu R. Linton MD

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana

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Michael G. Moore MD,

Michael G. Moore MD

Department of Otolaryngology/Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana

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Joseph S. Brigance MD,

Joseph S. Brigance MD

Department of Otolaryngology/Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana

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Don-John Summerlin DMD, MS,

Don-John Summerlin DMD, MS

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana

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Mark W. McDonald MD,

Corresponding Author

Mark W. McDonald MD

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana

Indiana University Health Proton Therapy Center, Bloomington, Indiana

First published: 17 December 2013

https://doi.org/10.1002/hed.23573

Citations: 33

This work was presented in part at the 95th annual meeting of the American Radium Society, April 27 to May 1, 2013, Scottsdale, Arizona.

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Abstract

Background

The purpose of this study was to report outcomes of proton therapy in head and neck adenoid cystic carcinoma.

Methods

We conducted a retrospective analysis of 26 patients treated between 2004 and 2012. Twenty patients (77%) had base of skull involvement; 19 (73%) were treated for initial disease and 7 (27%) for recurrent disease. Twenty patients were treated postoperatively, 6 after biopsy alone and 24 had positive margins or gross residual disease. Median dose delivered was 72 Gy (relative biological effectiveness [RBE]).

Results

Median follow-up was 25 months (range, 7–50 months). The 2-year overall survival was 93% for initial disease course and 57% for recurrent disease (p = .19). The 2-year local control was 95% for initial disease and 86% for recurrent disease (p = .48). The 2-year distant metastatic rate was 25%. Late toxicity of grade 0 or 1 was seen in 17 patients, grade 2 in 5, grade 3 in 2, grade 4 in 1, and grade 5 in 1.

Conclusion

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Volume37, Issue1

January 2015

Pages 117-124

Proton therapy for head and neck adenoid cystic carcinoma: Initial clinical outcomes

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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Proton therapy for head and neck adenoid cystic carcinoma: Initial clinical outcomes

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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