Original Article
Primary sarcomas of the salivary glands: Case series and literature review
Cara C. Cockerill MD,
Shiva Daram BA,
Adel K. El–Naggar MD,
Ehab Y. Hanna MD,
Randal S. Weber MD,
Michael E. Kupferman MD,
Cara C. Cockerill MD
The University of Texas Medical School at Houston, Houston, Texas
Search for more papers by this authorShiva Daram BA
Office of Student Affairs, Baylor College of Medicine, Houston, Texas
Search for more papers by this authorAdel K. El–Naggar MD
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorEhab Y. Hanna MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorRandal S. Weber MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCorresponding Author
Michael E. Kupferman MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1445, Houston, TX 77030. E-mail: [email protected]Search for more papers by this authorCara C. Cockerill MD,
Shiva Daram BA,
Adel K. El–Naggar MD,
Ehab Y. Hanna MD,
Randal S. Weber MD,
Michael E. Kupferman MD,
Cara C. Cockerill MD
The University of Texas Medical School at Houston, Houston, Texas
Search for more papers by this authorShiva Daram BA
Office of Student Affairs, Baylor College of Medicine, Houston, Texas
Search for more papers by this authorAdel K. El–Naggar MD
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorEhab Y. Hanna MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorRandal S. Weber MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorCorresponding Author
Michael E. Kupferman MD
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1445, Houston, TX 77030. E-mail: [email protected]Search for more papers by this authorEhab Y. Hanna, MD, was recused from consideration of this manuscript.
Abstract
Background
Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis.
Methods
We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010.
Results
Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively.
Conclusions
Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis. © 2013 Wiley Periodicals, Inc. Head Neck, 35: 1551–1557, 2013
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