Clinical Review
Prognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta-analysis
Jian Zang MD,
Chen Li MM,
Li-Na Zhao MD,
Mei Shi MD,
Yong-Chun Zhou MD,
Jian-Hua Wang MD,
Xin Li MM,
Jian Zang MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorChen Li MM
Department of Health Statistics, School of Public Health, Sichuan University, Chengdu, China
Search for more papers by this authorLi-Na Zhao MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorCorresponding Author
Mei Shi MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, No.127, West ChangleRoad, Xi'an 710032, China. E-mail: [email protected]Search for more papers by this authorYong-Chun Zhou MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorJian-Hua Wang MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorXin Li MM
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorJian Zang MD,
Chen Li MM,
Li-Na Zhao MD,
Mei Shi MD,
Yong-Chun Zhou MD,
Jian-Hua Wang MD,
Xin Li MM,
Jian Zang MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorChen Li MM
Department of Health Statistics, School of Public Health, Sichuan University, Chengdu, China
Search for more papers by this authorLi-Na Zhao MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorCorresponding Author
Mei Shi MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, No.127, West ChangleRoad, Xi'an 710032, China. E-mail: [email protected]Search for more papers by this authorYong-Chun Zhou MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorJian-Hua Wang MD
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorXin Li MM
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorAbstract
Background
The correlation between vascular endothelial growth factor (VEGF) overexpression and the clinical outcome of head and neck cancer remains inconclusive. This meta-analysis aimed to evaluate the prognostic value of VEGF in patients with head and neck cancer.
Methods
We searched Ovid MEDLINE, EMBASE and 2 Chinese science databases in order to enroll all eligible articles. Forty-seven studies were included in this meta-analysis. All results were evaluated by the random-effects model.
Results
VEGF overexpression is significantly associated with worse overall survival (OS; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.61–2.22) and progression-free survival (PFS; HR, 1.68; 95% CI, 1.33–2.12). Subgroup analysis reveals that VEGF overexpression is a significant poor predictor for nasopharyngeal cancer (HR, 1.66; 95% CI, 1.30–2.12) and salivary gland cancer (HR, 3.32; 95% CI, 1.61–6.84).
Conclusion
Our meta-analysis supports that VEGF overexpression is an available poor predictor for patients with head and neck cancer. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1507–1514, 2013
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