Diabetes/Metabolism Research and Reviews

Research Article

Circulating secreted frizzled-related protein 5 (Sfrp5) and wingless-type MMTV integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes mellitus

Yung-Chuan Lu

Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan

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Chao-Ping Wang,

Chao-Ping Wang

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Chia-Chang Hsu,

Chia-Chang Hsu

Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan

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Cheng-An Chiu,

Cheng-An Chiu

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Teng-Hung Yu,

Teng-Hung Yu

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Wei-Chin Hung,

Wei-Chin Hung

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Li-Fen Lu,

Li-Fen Lu

Division of Cardiac Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Fu-Mei Chung,

Fu-Mei Chung

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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I-Ting Tsai,

I-Ting Tsai

Department of Emergency, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Hsien-Chang Lin,

Hsien-Chang Lin

Li-Tzung Biotechnology, Inc., Kaohsiung, Taiwan

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Yau-Jiunn Lee,

Corresponding Author

Yau-Jiunn Lee

[email protected]

Lee's Endocrinologic Clinic, Pingtung, Taiwan

Correspondence to: Yau-Jiunn Lee, Lee's Endocrinologic Clinic, No. 130 Min-Tzu Rd, Pingtung 90000, Taiwan.

E-mail: [email protected]

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Yung-Chuan Lu,

Yung-Chuan Lu

Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan

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Chao-Ping Wang,

Chao-Ping Wang

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Chia-Chang Hsu,

Chia-Chang Hsu

Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan

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Cheng-An Chiu,

Cheng-An Chiu

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Teng-Hung Yu,

Teng-Hung Yu

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Wei-Chin Hung,

Wei-Chin Hung

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Li-Fen Lu,

Li-Fen Lu

Division of Cardiac Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Fu-Mei Chung,

Fu-Mei Chung

Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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I-Ting Tsai,

I-Ting Tsai

Department of Emergency, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

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Hsien-Chang Lin,

Hsien-Chang Lin

Li-Tzung Biotechnology, Inc., Kaohsiung, Taiwan

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Yau-Jiunn Lee,

Corresponding Author

Yau-Jiunn Lee

[email protected]

Lee's Endocrinologic Clinic, Pingtung, Taiwan

Correspondence to: Yau-Jiunn Lee, Lee's Endocrinologic Clinic, No. 130 Min-Tzu Rd, Pingtung 90000, Taiwan.

E-mail: [email protected]

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First published: 07 May 2013

https://doi.org/10.1002/dmrr.2426

Citations: 57

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Abstract

Background

Secreted frizzled-related protein 5 (Sfrp5), an endogenous inhibitor of wingless-type MMTV integration site family (Wnt) signalling, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes mellitus (T2DM). Wnt member 5a (Wnt5a) is a representative ligand, and recent reports suggest that Wnt5a is involved in inflammatory diseases and metabolic disorders. The aim of this study was to investigate whether plasma Wnt5a and Sfrp5 levels are altered in patients with T2DM.

Methods

Plasma Sfrp5 and Wnt5a concentrations were measured through enzyme-linked immunosorbent assay in type 2 diabetic and nondiabetic subjects.

Results

A total of 82 patients with T2DM and 42 nondiabetic subjects were studied. Plasma Sfrp5 levels were found to be elevated in patients with T2DM (9.4 ± 9.0 vs 7.4 ± 10.9 ng/mL, p = 0.006). In contrast, Wnt5a levels were decreased (6.8 ± 12.6 vs 9.1 ± 4.0 ng/dL, p < 0.001). Increasing concentrations of Sfrp5 were independently and significantly associated with T2DM. Multiple logistic regression analysis revealed Sfrp5 as an independent association factor for T2DM, even after full adjustment of known biomarkers. In a multiple linear regression analysis, only the fasting glucose level was positively associated with the plasma Sfrp5 level.

Conclusions

References

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Citing Literature

Volume29, Issue7

October 2013

Pages 551-556

Circulating secreted frizzled-related protein 5 (Sfrp5) and wingless-type MMTV integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes mellitus

Abstract

Background

Methods

Results

Conclusions

References

Citing Literature

References

Information

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Circulating secreted frizzled-related protein 5 (Sfrp5) and wingless-type MMTV integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes mellitus

Abstract

Background

Methods

Results

Conclusions

References

Citing Literature

References

Related

Information