Critical Review
Biomimetic and Biological Applications of DNA Coacervates
Yuqi Zeng,
Long Zhao,
Yihao Liu,
Tianhuan Peng,
Yifan Lyu,
Quan Yuan,
Yuqi Zeng
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
These authors contributed equally.
Search for more papers by this authorLong Zhao
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
These authors contributed equally.
Search for more papers by this authorYihao Liu
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
Search for more papers by this authorCorresponding Author
Tianhuan Peng
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yifan Lyu
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
Furong Laboratory, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Quan Yuan
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorYuqi Zeng,
Long Zhao,
Yihao Liu,
Tianhuan Peng,
Yifan Lyu,
Quan Yuan,
Yuqi Zeng
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
These authors contributed equally.
Search for more papers by this authorLong Zhao
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
These authors contributed equally.
Search for more papers by this authorYihao Liu
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
Search for more papers by this authorCorresponding Author
Tianhuan Peng
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yifan Lyu
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
Furong Laboratory, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Quan Yuan
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorFirst published: 19 April 2025
Abstract
Comprehensive Summary
Recent progress in nanotechnology and synthetic biology has demonstrated the potential of DNA coacervates for biomimetic and biological applications. DNA coacervates are micron-scale, membrane-free, spherical structures formed by liquid-liquid phase separation of DNA materials. They uniquely combine the programmability of DNA with the fluidic properties of coacervates, allowing for controlled modulation of their structures, biomimetic and biological functions, and dynamic behaviors through rational sequence design. This review summarizes methods for the formation of different DNA coacervates and explores their extensive applications in biomimicry, biosensing and therapeutics. Limitations and prospects of DNA coacervates are also discussed.
Key Scientists
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