Concise Report
Palladium-Catalyzed Construction of Phthalides Bearing Two Adjacent Stereocenters through Retro-oxa-Michael Addition
Li-Xia Liu,
Tong Niu,
Yu-Qing Bai,
Yong-Gui Zhou,
Li-Xia Liu
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorTong Niu
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
Search for more papers by this authorYu-Qing Bai
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
Search for more papers by this authorCorresponding Author
Yong-Gui Zhou
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032 China
E-mail: [email protected]Search for more papers by this authorLi-Xia Liu,
Tong Niu,
Yu-Qing Bai,
Yong-Gui Zhou,
Li-Xia Liu
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorTong Niu
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
Search for more papers by this authorYu-Qing Bai
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
Search for more papers by this authorCorresponding Author
Yong-Gui Zhou
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023 China
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032 China
E-mail: [email protected]Search for more papers by this authorFirst published: 21 August 2024
Comprehensive Summary
Optically active phthalides are prevalent in many natural and bioactive products. Herein, a novel dynamic kinetic resolution of isobenzofuranone derivatives through palladium-catalyzed asymmetric allylic alkylation has been developed to synthesize phthalide derivatives bearing vicinal quaternary and tertiary stereocenters with high yields, showing excellent chemo-, enantio- and diastereoselectivity. Furthermore, gram-scale experiment underwent smoothly and the transformation of product could build a bridged bicyclic skeleton.
Supporting Information
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