Volume 43, Issue 18
Isocyclic Compounds

ChemInform Abstract: Synthesis of Enantioenriched γ-Quaternary Cycloheptenones Using a Combined Allylic Alkylation/Stork—Danheiser Approach: Preparation of Mono-, Bi-, and Tricyclic Systems.

Nathan B. Bennett

Nathan B. Bennett

Div. Chem. Chem. Eng., Calif. Inst. Technol., Pasadena, CA 91125, USA

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Allen Y. Hong

Allen Y. Hong

Div. Chem. Chem. Eng., Calif. Inst. Technol., Pasadena, CA 91125, USA

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Andrew M. Harned

Andrew M. Harned

Div. Chem. Chem. Eng., Calif. Inst. Technol., Pasadena, CA 91125, USA

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Brian M. Stoltz

Brian M. Stoltz

Div. Chem. Chem. Eng., Calif. Inst. Technol., Pasadena, CA 91125, USA

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First published: 05 April 2012

Abstract

The addition of Grignard or organolithium compounds to enantioenriched vinylogous ester (I) followed by finely tuned quenching conditions affords β-functionalized cycloheptenones.

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