Volume 43, Issue 18
Preparative Organic Chemistry

ChemInform Abstract: Rapid Synthesis of Highly Functionalized α-Amino Amides and Medium Ring Lactones Using Multicomponent Reactions of Amino Alcohols and Isocyanides.

Martin Bachman

Martin Bachman

Dep. Chem., Univ. Coll., London WC1H 0AJ, UK

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Sam E. Mann

Sam E. Mann

Dep. Chem., Univ. Coll., London WC1H 0AJ, UK

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Tom D. Sheppard

Tom D. Sheppard

Dep. Chem., Univ. Coll., London WC1H 0AJ, UK

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First published: 05 April 2012

Abstract

Four-component reactions between amino alcohols, aldehydes, isocyanides and aromatic thiols provide arylthioalkylamino acid amides (18 examples) under microwave heating.

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