Volume 42, Issue 21
Heterocyclic Compounds

ChemInform Abstract: Probing the Stereoselectivity of P-Glycoprotein—Synthesis, Biological Activity and Ligand Docking Studies of a Set of Enantiopure Benzopyrano[3,4-b][1,4]oxazines.

Ishrat Jabeen

Ishrat Jabeen

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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Penpun Wetwitayaklung

Penpun Wetwitayaklung

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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Freya Klepsch

Freya Klepsch

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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Zehida Parveen

Zehida Parveen

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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Peter Chiba

Peter Chiba

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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Gerhard F. Ecker

Gerhard F. Ecker

Dep. Med. Chem., Med. Univ. Wien, A-1090 Wien, Austria

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First published: 28 April 2011

Abstract

Some of the title benzopyranooxazines and their precursors (I)/(II), e.g. (Ib), (Ic), (IIb), (IIc), and (IIIc) demonstrate significant P-glycoprotein inhibitory activity.

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