Conversation in cardiology: Is there a need for clinical trials for the nonhyperemic pressure ratios?
Corresponding Author
Morton J. Kern MD
Veterans Administration Long Beach Health Care System, Long Beach, and University of California Irvine, California
University of California Irvine, Orange, California
Correspondence
Morton J. Kern, Veterans Administration Long Beach Health Care System, 5901 E 7th St., Long Beach, CA 90822.
Email: [email protected]
Search for more papers by this authorColin Berry MD
Professor of Medicine, University of Glasgow, Glasgow, Scotland
Search for more papers by this authorWilliam Fearon MD
Professor of Medicine Director, Interventional Cardiology Stanford, University School of Medicine, Palo Alto, California
Search for more papers by this authorAllen Jeremias MD
Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory, St. Francis Hospital, The Heart Center®, Associate Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorNils Johnson MD
Weatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, Texas
Search for more papers by this authorDavid Kandzari MD
Director, Interventional Cardiology, Piedmont Heart Institute Chief Scientific Officer, Piedmont Healthcare, Atlanta, Georgia
Search for more papers by this authorAjay Kirtane MD
Associate Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorJeffery Moses MD
Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorMitchell Krucoff MD
Professor Medicine/Cardiology Duke University Medical Center Director, Cardiovascular Devices Unit Director, eECG Core Laboratories Duke Clinical Research Institute, Raleigh Durham, North Carolina
Search for more papers by this authorGregg Stone MD
Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorCorresponding Author
Morton J. Kern MD
Veterans Administration Long Beach Health Care System, Long Beach, and University of California Irvine, California
University of California Irvine, Orange, California
Correspondence
Morton J. Kern, Veterans Administration Long Beach Health Care System, 5901 E 7th St., Long Beach, CA 90822.
Email: [email protected]
Search for more papers by this authorColin Berry MD
Professor of Medicine, University of Glasgow, Glasgow, Scotland
Search for more papers by this authorWilliam Fearon MD
Professor of Medicine Director, Interventional Cardiology Stanford, University School of Medicine, Palo Alto, California
Search for more papers by this authorAllen Jeremias MD
Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory, St. Francis Hospital, The Heart Center®, Associate Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorNils Johnson MD
Weatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, Texas
Search for more papers by this authorDavid Kandzari MD
Director, Interventional Cardiology, Piedmont Heart Institute Chief Scientific Officer, Piedmont Healthcare, Atlanta, Georgia
Search for more papers by this authorAjay Kirtane MD
Associate Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorJeffery Moses MD
Professor of Medicine, Columbia University, New York, New York
Search for more papers by this authorMitchell Krucoff MD
Professor Medicine/Cardiology Duke University Medical Center Director, Cardiovascular Devices Unit Director, eECG Core Laboratories Duke Clinical Research Institute, Raleigh Durham, North Carolina
Search for more papers by this authorGregg Stone MD
Professor of Medicine, Columbia University, New York, New York
Search for more papers by this author
REFERENCES
- 1Patel MR, Calhoon JH, Dehmer GJ, et al. ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS. 2017 Appropriate use criteria for coronary revascularization in patients with stable ischemic heart disease: a report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2017; 69: 2212-2241.
- 2Van't Veer M, Pijls NHJ, Hennigan B, et al. Comparison of different diastolic resting indexes to iFR: are they all equal? J Am Coll Cardiol. 2017; 70: 3088-3096.
- 3Ahn JM, Park DW, Shin ES, et al. IRIS-FFR Registry: Prognostic Performance of 5 Resting Pressure-Derived Indexes of Coronary Physiology. San Diego, CA: TCT; 2018.
- 4Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J. 2019; 40(2): 87-165. https://doi.org/10.1093/eurheartj/ehy394.
- 5Jeremias A, Maehara A, Genereux P, et al. Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J Am Coll Cardiol. 2014; 63: 1253-1261.
- 6Hennigan B, Oldroyd KG, Berry C, et al. Discordance between resting and hyperemic indices of coronary stenosis severity: the VERIFY 2 study (a comparative study of resting coronary pressure gradient, instantaneous wave-free ratio and fractional flow reserve in an unselected population referred for invasive angiography). Circ Cardiovasc Interv. 2016; 9(11):e004016.
- 7Johnson NP, Jeremias A, Zimmermann FM, et al. Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment (CONTRAST). JACC Cardiovasc Interv. 2016; 9(8): 757-767. https://doi.org/10.1016/j.jcin.2015.12.273.
- 8Kern MJ, Seto AH. dPR, another diastolic resting pressure ratio: refinements and nuances with identical results. Circ Cardiovasc Interv. 2018; 11:e007540.
- 9Svanerud J, Ahn JM, Jeremias A, et al. Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the resting full-cycle ratio (VALIDATE RFR) study. EuroIntervention. 2018; 14(7): 806-814. https://doi.org/10.4244/EIJ-D-18-00342.
- 10Ligthart J, Masdjedi K, Witberg K, et al. Validation of resting diastolic pressure ratio calculated by a novel algorithm and its correlation with Pd/Pa, instantaneous wave-free ratio and fractional flow reserve: the dPR-study. Circ Cardiovasc Interv. 2018; 11:e006911. https://doi.org/10.1161/CIRCINTERVENTIONS.118.006911.
- 11Lee JM, Choi KH, Park J, et al. Physiological and clinical assessment of resting physiological indexes. Circulation. 2019; 139(7): 889-900. https://doi.org/10.1161/CIRCULATIONAHA.118.037021.
- 12Johnson NP, Li W, Chen X, et al. Diastolic pressure ratio (dPR): new approach and validation versus the instantaneous wave-free ratio (iFR). Eur Heart J. 2019; 40:ehz230. https://doi.org/10.1093/eurheartj/ehz230.
- 13Berry C, McClure JD, Oldroyd KG. Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials. Circulation. 2017; 136(24): 2389-2391.
