Non-infectious thrombosis of the melody® valve: A tale of two cities
Andrew E. Schneider MD
Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorJeffrey W. Delaney MD
Division of Pediatric Cardiology, Department of Pediatrics, University of Nebraska, Children's Hospital and Medical Center, Omaha, Nebraska
Search for more papers by this authorCorresponding Author
Allison K. Cabalka MD
Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota
Division of Cardiovascular Diseases, Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
Correspondence to: Allison K. Cabalka, MD, Professor of Pediatrics, Mayo Clinic, Gonda 6, 138-NW, 200 First Street SW, Rochester, MN 55905. E-mail: [email protected]Search for more papers by this authorAndrew E. Schneider MD
Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorJeffrey W. Delaney MD
Division of Pediatric Cardiology, Department of Pediatrics, University of Nebraska, Children's Hospital and Medical Center, Omaha, Nebraska
Search for more papers by this authorCorresponding Author
Allison K. Cabalka MD
Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota
Division of Cardiovascular Diseases, Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
Correspondence to: Allison K. Cabalka, MD, Professor of Pediatrics, Mayo Clinic, Gonda 6, 138-NW, 200 First Street SW, Rochester, MN 55905. E-mail: [email protected]Search for more papers by this authorConflict of interest: Nothing to report.
Abstract
Bioprosthetic valve thrombosis is an uncommon complication. We report two young women with prior uncomplicated percutaneous pulmonary valve replacement (Melody®, Medtronic, Inc. Minneapolis, MN) who later developed symptomatic pulmonary emboli and pulmonary valve dysfunction without evidence of infection. Thrombophilia risk factors included oral contraceptive use and mild thrombophilia. Both experienced recovery of valve function following anticoagulation. Acute changes in Melody® valve function should prompt a thorough investigation for and treatment of potential thrombotic causes. © 2016 Wiley Periodicals, Inc.
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