Volume 82, Issue 7 pp. E842-E848
E-ONLY: Coronary Artery Disease

Porcine model of intracoronary pulverization of stent struts by rotablation atherectomy

Thuy Tran Quang MD, PhD

Thuy Tran Quang MD, PhD

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

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Raja Hatem MD

Raja Hatem MD

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

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Guy Rousseau PhD

Guy Rousseau PhD

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

Département de Pharmacologie, Université de Montréal, Montréal, Québec, Canada

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Bruno Dube MS

Bruno Dube MS

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

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Caroline Samson MD

Caroline Samson MD

Département de Radiographie, Hôpital de Sacré-Cœur de Montréal, Montréal, Québec, Canada

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Erick Schampaert MD

Erick Schampaert MD

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

Département de Cardiologie, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

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Thierry Charron MD

Corresponding Author

Thierry Charron MD

Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

Département de Cardiologie, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

Correspondence to: Dr. Thierry Charron, M.D., 5400, Boul. Gouin Ouest, Montréal, Québec H4J 1C5, Canada. E-mail: [email protected]Search for more papers by this author
First published: 04 September 2012
Citations: 13

Conflict of interest: Nothing to report.

Abstract

Objective

To evaluate the feasibility and safety of rotablation atherectomy in a suboptimally expanded stent.

Methods

Seven pigs underwent suboptimal stent expansion in the left anterior descending coronary. Pulverization of the stent struts was performed by rotablation atherectomy with two different burr sizes. Two types of control porcine models were used: pigs with fully expanded stents and pigs without stents. Continuous electrocardiogram readings as well as microscopic and radiologic analysis of cardiac tissue were performed.

Results

Rotablation atherectomy reduces the suboptimally expanded stent by (26.95 ± 5.03)%. Ninety-five percent of the metal microparticles, imbedded in the suboptimally expanded stent group cardiac tissue, are less than 15 μm. Transient vasospasm and ST segments elevations were observed during rotablation atherectomy, which returned to basal conditions at the end of the intervention.

Conclusion

Our study demonstrated the feasibility and safety of using rotablation atherectomy to pulverize stent struts in a suboptimally expanded stent. © 2012 Wiley Periodicals, Inc.

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