Three Undescribed Protoilludane-Type Sesquiterpene Aryl Esters from Armillaria gallica
Jing-Jing Zhang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Southwest United Graduate School, Kunming, 650092 China
Search for more papers by this authorSong-Xue Yang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorXing-Jie Zhang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorNa Li
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorXiao-Ting He
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorCorresponding Author
Wei-Lie Xiao
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Southwest United Graduate School, Kunming, 650092 China
Search for more papers by this authorCorresponding Author
Li-Jun Cheng
Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, Zhaotong University, Zhaotong, 65700 China
Search for more papers by this authorCorresponding Author
Xiao-Li Li
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorJing-Jing Zhang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Southwest United Graduate School, Kunming, 650092 China
Search for more papers by this authorSong-Xue Yang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorXing-Jie Zhang
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorNa Li
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorXiao-Ting He
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorCorresponding Author
Wei-Lie Xiao
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Southwest United Graduate School, Kunming, 650092 China
Search for more papers by this authorCorresponding Author
Li-Jun Cheng
Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, Zhaotong University, Zhaotong, 65700 China
Search for more papers by this authorCorresponding Author
Xiao-Li Li
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 China
Search for more papers by this authorAbstract
Three previously undescribed protoilludane-type sesquiterpene aryl esters, armillanals A−C (1–3), along with seven known ones (4–10) were obtained from Armillaria gallica Marxm. & Romagn. Compounds 1 and 2 were a rare class of sesquiterpenes featuring the Δ2(3) and Δ12(13)-protoilludane skeleton. Their structures were established by extensive spectroscopic methods. Based on electronic circular dichroism (ECD) calculations, the absolute configurations of three new compounds (1–3) were determined. The anti-inflammatory activity of compounds 1–10 was screened and compound 3 could dose-dependently decrease the level of lactate dehydrogenase, showing IC50 value of 4.525 μM.
Graphical Abstract
Conflict of Interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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